Medicine:Free fraction

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Short description: Pharmacokinetics parameter

The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions:

  • Plasma free fraction, previously referred to as ƒ1,[1] is now referred to as ƒP according to consensus nomenclature.[2]
  • Tissue free fractionND), previously referred to as ƒ2[1]

The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.

See also

References

  1. 1.0 1.1 Roger N. Gunn; Steve R. Gunn; Federico E. Turkheimer; Vincent J. Cunningham (2002). "Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling". J. Cereb. Blood Metab. 22 (4): 1425–1439. doi:10.1097/00004647-200212000-00003. PMID 12468888. Table
  2. Innis, R.B.; Cunningham, VJ; Delforge, J; Fujita, M; Gjedde, A; Gunn, RN; Holden, J; Houle, S et al. (2007). "Consensus nomenclature for in vivo imaging of reversibly binding radioligands". J Cereb Blood Flow Metab 27 (9): 1533–1539. doi:10.1038/sj.jcbfm.9600493. PMID 17519979. 

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