Medicine:Hepatoblastoma

From HandWiki
Short description: Liver cancer occurring in infants and children
Hepatoblastoma
Hepatoblastoma - 2 - very high mag.jpg
Micrograph of a hepatoblastoma. H&E stain.

Hepatoblastoma is a malignant liver cancer occurring in infants and children and composed of tissue resembling fetal liver cells, mature liver cells, or bile duct cells. They usually present with an abdominal mass. The disease is most commonly diagnosed during a child's first three years of life.[1] Alpha-fetoprotein (AFP) levels are commonly elevated, but when AFP is not elevated at diagnosis the prognosis is poor.[2]

Signs and symptoms

Patients are usually asymptomatic at diagnosis.[3] As a result, disease is often advanced at diagnosis.

Pathophysiology

Micrograph showing a hepatoblastoma (right of image) and normal liver (left of image). H&E stain.
Liver tumor types by relative incidence in adults in the United States, with hepatoblastoma at right[4]

Hepatoblastomas originate from immature liver precursor cells, are typically unifocal, affect the right lobe of the liver more often than the left lobe, and can metastasize. They are categorized into two types: "Epithelial Type" and "Mixed Epithelial / Mesenchymal Type."[citation needed]

Individuals with familial adenomatous polyposis (FAP), a syndrome of early-onset colonic polyps and adenocarcinoma, frequently develop hepatoblastomas.[5][6] Also, beta-catenin mutations have been shown to be common in sporadic hepatoblastomas, occurring in as many as 67% of patients.[7][8]

Recently, other components of the Wnt signaling pathway have also demonstrated a likely role in constitutive activation of this pathway in the causation of hepatoblastoma.[8][9] Accumulating evidence suggests that hepatoblastoma is derived from a pluripotent stem cell.[10]

Syndromes with an increased incidence of hepatoblastoma include Beckwith–Wiedemann syndrome, trisomy 18, trisomy 21, Acardi syndrome, Li–Fraumeni syndrome, Goldenhar syndrome, von Gierke disease, and familial adenomatous polyposis.[11]

Diagnosis

The most common method of testing for hepatoblastoma is a blood test checking the alpha-fetoprotein level. Alpha-fetoprotein (AFP) is used as a biomarker to help determine the presence of liver cancer in children. At birth, infants have relatively high levels of AFP, which fall to normal adult levels by the second year of life. The normal level for AFP in children has been reported as lower than 50 nanograms per milliliter (ng/ml) and 10 ng/ml in adults. An AFP level greater than 500 ng/ml is a significant indicator of hepatoblastoma. AFP is also used as an indicator of treatment success. If treatments are successful in removing the cancer, the AFP level is expected to return to normal.[12]

Treatment

Surgical removal of the tumor, neoadjuvant chemotherapy prior to tumor removal, and liver transplantation have been used to treat these cancers.[13][14] Primary liver transplantation provides high, long term, disease-free survival rate in the range of 80%, in cases of complete tumor removal and adjuvant chemotherapy survival rates approach 100%.[15][16] The presence of metastases is the strongest predictor of a poor prognosis.[17]

References

  1. ↑ "Archived copy". http://hepatoblastoma.mditv.com/generalinfo. [full citation needed]
  2. ↑ "Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience". European Journal of Cancer 44 (4): 545–550. March 2008. doi:10.1016/j.ejca.2007.11.022. PMID 18166449. 
  3. ↑ Willert, Jennifer. "Pediatric Hepatoblastoma Clinical Presentation: History, Physical, Causes". http://emedicine.medscape.com/article/986802-clinical. 
  4. ↑ Table 37.2 in: Sternberg, Stephen (2012). Sternberg's diagnostic surgical pathology. Place of publication not identified: LWW. ISBN 978-1-4511-5289-0. OCLC 953861627. 
  5. ↑ "The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds". The Journal of Pediatrics 147 (2): 263–266. August 2005. doi:10.1016/j.jpeds.2005.04.019. PMID 16126064. 
  6. ↑ "Familial adenomatous polyposis in two brothers with hepatoblastoma: implications for diagnosis and screening". Pediatric Blood & Cancer 47 (6): 851–854. November 2006. doi:10.1002/pbc.20556. PMID 16106429. 
  7. ↑ "Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam". Cancer Research 60 (11): 2864–2868. June 2000. PMID 10850429. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10850429. 
  8. ↑ 8.0 8.1 "Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver". Gastroenterology 129 (1): 285–302. July 2005. doi:10.1053/j.gastro.2005.04.013. PMID 16012954. 
  9. ↑ "Elevated expression of Wnt antagonists is a common event in hepatoblastomas". Clinical Cancer Research 11 (12): 4295–4304. June 2005. doi:10.1158/1078-0432.CCR-04-1162. PMID 15958610. 
  10. ↑ "Stem-like cells in hepatoblastoma". Medical and Pediatric Oncology 39 (5): 504–507. November 2002. doi:10.1002/mpo.10175. PMID 12228907. 
  11. ↑ Zimmerman A, Saxena R. Hepatoblastoma. In: WHO Classification of Tumours of the Digestive System, 4th, Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds), IARC, Lyon 2010. p.229.
  12. ↑ "A novel site on gamma 3 subunits important for assembly of GABA(A) receptors". The Journal of Biological Chemistry 277 (34): 30656–30664. August 2002. doi:10.1074/jbc.M203597200. PMID 12065588. 
  13. ↑ "Treatment outcomes for hepatoblastoma: an institution's experience over two decades". Pediatric Surgery International 23 (2): 103–109. February 2007. doi:10.1007/s00383-006-1834-1. PMID 17119981. 
  14. ↑ "Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience". Pediatric Blood & Cancer 42 (1): 74–83. January 2004. doi:10.1002/pbc.10376. PMID 14752798. 
  15. ↑ Pediatric Hepatoblastoma at eMedicine
  16. ↑ "Liver transplantation for hepatoblastoma: indications and contraindications in the modern era". Pediatric Transplantation 9 (5): 557–565. October 2005. doi:10.1111/j.1399-3046.2005.00354.x. PMID 16176410. 
  17. ↑ "Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group". Journal of Clinical Oncology 20 (12): 2798–2804. June 2002. doi:10.1200/JCO.2002.06.102. PMID 12065556. http://www.jco.org/cgi/pmidlookup?view=long&pmid=12065556. 

External links

  • humpath #2775 (Pathology images)
Classification
External resources



Retrieved from "https://handwiki.org/wiki/index.php?title=Medicine:Hepatoblastoma&oldid=2559922"