Medicine:Hydrophilization
From HandWiki
Hydrophilization is a process used on hydrophobic drugs to increase their release rate from capsules, which depends on the rate of dissolution, by covering the surfaces of their particles with minute droplets of a dissolved hydrophilic polymer (such as methyl cellulose or hydroxyethyl cellulose).[1][2] In tablet or capsule formulations, this enhances the dissolution and disintegration of the drug.[2]
References
- ↑ Panraksa, Pattaraporn; Udomsom, Suruk; Rachtanapun, Pornchai; Chittasupho, Chuda; Ruksiriwanich, Warintorn; Jantrawut, Pensak (November 2020). "Hydroxypropyl Methylcellulose E15: A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer" (in en). Polymers 12 (11): 2666. doi:10.3390/polym12112666. ISSN 2073-4360. PMID 33198094.
- ↑ 2.0 2.1 "Effect of hydrophilization of hydrophobic drugs on release rate from capsules". Journal of Pharmaceutical Sciences 67 (7): 935–9. July 1978. doi:10.1002/jps.2600670716. PMID 660511.
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