Medicine:Pegylated interferon
From HandWiki
Pegylated interferon (PEG-IFN) is a class of medication that includes three different drugs as of 2012:[1]
- Pegylated interferon-alpha-2a
- Pegylated interferon-alpha-2b
- Pegylated interferon beta-1a[2]
In these formulations, Polyethylene glycol (PEG) is added to make interferon last longer in the body.[3] They are used to treat both hepatitis B,[4] hepatitis C[1] and multiple sclerosis.[2]
Pegylated interferon is contraindicated in patients with hyperbilirubinaemia.[citation needed]
References
- ↑ 1.0 1.1 editor, Emilio Jirillo (2008). Hepatitis C virus disease : immunobiology and clinical applications ([Online-Ausg.] ed.). New York: Springer. pp. 237. ISBN 978-0-387-71375-5. https://books.google.com/books?id=yjzazAgMWEUC&pg=PA237.
- ↑ 2.0 2.1 Kieseier BC, Calabresi PA.; Calabresi (2012). "PEGylation of Interferon-β-1a: A Promising Strategy in Multiple Sclerosis". CNS Drugs 26 (3): 205–14. doi:10.2165/11596970-000000000-00000. PMID 22201341. http://adisonline.com/cnsdrugs/Abstract/2012/26030/PEGylation_of_Interferon___1a__A_Promising.2.aspx.
- ↑ "Hepatology Focus: Update on Hepatitis C Treatment: Pegylated Interferon". February 15, 2001. http://www.medscape.com/viewarticle/407963_5.
- ↑ Clinical Hepatology. [S.l.]: Springer Berlin Heidelberg. 2010. pp. 765. ISBN 978-3-642-04509-7. https://books.google.com/books?id=lrPX8C4p90QC&pg=PA765.
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