Medicine:Wolcott–Rallison syndrome

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Wolcott–Rallison syndrome
Other namesEarly-onset diabetes mellitus with multiple epiphyseal dysplasia
Walcott-Rallison Syndrome.png
Radiograph of a WRS child presenting with dysplastic bone growth in various regions of the body.

Wolcott–Rallison syndrome, WRS, is a rare, autosomal recessive disorder with infancy-onset diabetes mellitus, multiple epiphyseal dysplasia, osteopenia, mental retardation or developmental delay, and hepatic and renal dysfunction as main clinical findings. Patients with WRS have mutations in the EIF2AK3 gene, which encodes the eukaryotic translation initiation factor 2-alpha kinase 3.[1] [2] Other disease names include multiple epiphyseal dysplasia and early-onset diabetes mellitus.[3] Most patients with this disease do not survive to adulthood .[4] The majority of WRS patients die from fulminant hepatitis during childhood.[5] There are few reported cases for this disease. Of the 54 families worldwide with reported WRS cases, 22.2% of them are from the Kingdom of Saudi Arabia.[5] Of the 23 WRS patients in Saudi Arabia, all but one is the result of consanguineous marriages.[5] Another country where WRS cases have been found is Kosovo. Here, the Albanian population is also known for consanguineous marriages, but there were some cases involving patients from non-consanguineous parents that were carriers for the same mutant allele.[4]

Signs and symptoms

Genetics

The main focus for this autosomal recessive disease is mutations to the EIF2AK3 gene. This gene is located on the short arm of chromosome 2 (2p11.2).[3] In unrelated families, different mutations have been observed in the EIF2AK3 gene, including missense and nonsense mutations.[3] For some cases for unrelated families, identical mutations were rarely observed.[citation needed]

The EIKF2AK3 gene codes for PERK (pancreatic endoplasmic reticulum kinase), an explanation for the spectrum of symptoms. PERK is associated with the activity of beta cells in the pancreas. Beta cells are needed for the proper release of insulin into the blood stream after an increase in blood glucose.[4] This kinase is needed for the control of protein levels in the endoplasmic reticulum and is linked to ribosome activity.[6] The endoplasmic reticulum is a major protein sorting and processing center in every body cell. A broad range of bodily systems is affected, including pancreas, kidney, liver, bone, and nervous system, because of deficient stress response to improperly folded proteins inside the endoplasmic reticulum.[4] This is part of the reason why patients suffer from multiple epiphyseal dysplasia and osteopenia.[citation needed]

Diagnosis

Initially, patients with neonatal or early-childhood onset diabetes are possible candidates for having Wolcott–Rallison syndrome.[1] The other features include multiple epiphyseal dysplasia, osteopenia, intellectual disability, and hepatic and renal dysfunction.[1] Patients having features that suggest Wolcott–Rallison syndrome can be referred for genetics testing. The key way to test for this disease is through genetic testing for EIKF2AK3 mutations.[7] Molecular genetic analysis can be done for the patient and the parents to test for inherited or de novo mutations. It can also show whether the patient's parents are heterozygotes or homozygotes for the normal genotype.[4] X-rays can show bone age in relation to actual age. In typical WRS patients the bone age is a few years less than the chronological age.[4][5][8][9] Hypothyroidism is rare in WRS patients but can occur.[4]

Treatment

The most common method to manage hyperglycemia and diabetes is with an insulin pump.[9] In infants and very young children long-acting insulins like Glargine and Levemir are preferred to prevent recurrent hypoglycemia.[10] As soon as Walcott-Rallison syndrome is the diagnosis, therapy plans need to be drawn up along with frequent checkups to monitor kidney and liver function and adjust insulin treatment.[4] In the few cases that develop hypothyroidism, treatment with thyroxine is indicated, with the target to maintain normal circulating thyroid stimulating hormone (thyrotropin) concentrations.[4]

References

  1. ↑ 1.0 1.1 1.2 "Wolcott-Rallison syndrome with 3-hydroxydicarboxylic aciduria and lethal outcome". Journal of Inherited Metabolic Disease 31 (Suppl 2): S293-7. December 2008. doi:10.1007/s10545-008-0866-1. PMID 18500571. 
  2. ↑ "A novel mutation in the EIF2AK3 gene with variable expressivity in two patients with Wolcott-Rallison syndrome". Clinical Genetics 70 (1): 34–8. July 2006. doi:10.1111/j.1399-0004.2006.00632.x. PMID 16813601. 
  3. ↑ 3.0 3.1 3.2 McKusick, Victor. "Epiphyseal Dysplasia, Multiple, with Early-Onset Diabetes". Johns Hopkins University. http://www.omim.org/entry/226980?search=226980&highlight=226980. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 "Primary hypothyroidism and nipple hypoplasia in a girl with Wolcott-Rallison syndrome". European Journal of Pediatrics 173 (4): 529–31. April 2014. doi:10.1007/s00431-013-2189-y. PMID 24194294. 
  5. ↑ 5.0 5.1 5.2 5.3 "Frequency and spectrum of Wolcott-Rallison syndrome in Saudi Arabia: a systematic review". The Libyan Journal of Medicine 8 (1): 21137. June 2013. doi:10.3402/ljm.v8i0.21137. PMID 23759358. 
  6. ↑ "Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure". Journal of Medical Genetics 42 (12): 893–902. December 2005. doi:10.1136/jmg.2005.030791. PMID 15772126. 
  7. ↑ "Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity". Diabetes 53 (7): 1876–83. July 2004. doi:10.2337/diabetes.53.7.1876. PMID 15220213. 
  8. ↑ "Short stature in child with early-onset diabetes". European Journal of Pediatrics 172 (9): 1255–7. September 2013. doi:10.1007/s00431-013-2007-6. PMID 23644647. 
  9. ↑ 9.0 9.1 "Wolcott-Rallison syndrome". Orphanet Journal of Rare Diseases 5 (1): 29. November 2010. doi:10.1186/1750-1172-5-29. PMID 21050479. 
  10. ↑ Sreeramaneni, Poorna Gopal Azad., & Ambula, S. R. V. (2017). Ketoacidosis in Neonatal Diabetes Mellitus, Part of Wolcott-Rallison Syndrome. The American Journal of Case Reports, 18, 719–722. http://www.amjcaserep.com/abstract/index/idArt/902804

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