Software:i2b2
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 i2b2 v1.7.12a web application with elements Clinical Trials, Demographics, and Laboratory Tests extended in the concept tree | |
| Stable release | 1.7.12a
/ December 2019[1] |
|---|---|
| Repository | github |
| Written in | Java |
| Type | Data warehouse |
| License | MPLv2 |
| Website | www |
i2b2 (Integrating Biology and the Bedside) is an open-source data warehouse designed to store large amounts of healthcare and medical data so that it can be used for cohort selection, hypothesis generation or ad-hoc analysis in translational research. The platform was first introduced at the AMIA Annnual Symposium in 2006 and was "one of the sponsored initiatives of the NIH Roadmap National Centers for Biomedical Computing".[2][non-primary source needed] It was further introduced in more detail in 2010 with more details on implementation details, such as the underlying star schema with a central observation fact table for modelling the data.[3][non-primary source needed]
The interface is focused around cohort selection where the user can drag and drop items from a concept tree into a Venn diagram like mask to represent a logical relation. i2b2 additionally supports querying complex temporal relations using multiple events (i.e. an event occurs before or after another event). The platform supports the use of plug-ins in its web-interface and comes with several plug-ins pre-installed, such as a timeline plug-in visualizing the longitudinal information.
In 2012 Johnson & Johnson, in partnership with Recombinant Data Corporation, developed tranSMART on top of i2b2. However, focusing on primarily pharmaceutical use-cases and supporting high-dimensional omics data, the platform does not support longitudinal data, i.e. the time information from the data is not retained.
In May 2017, the tranSMART Foundation merged with the i2b2 Foundation to create an organization with the key mission to advance the field of precision medicine.
See also
References
- ↑ "Current releases of the platform" (in en-US). https://www.i2b2.org/software/index.html.
- ↑ Murphy, Shawn N.; Mendis, Michael E.; Berkowitz, David A.; Kohane, Isaac; Chueh, Henry C. (2006). "Integration of clinical and genetic data in the i2b2 architecture". AMIA Annual Symposium Proceedings 2006: 1040. PMID 17238659.>
- ↑ Murphy, S. N.; Weber, G.; Mendis, M.; Gainer, V.; Chueh, H. C.; Churchill, S.; Kohane, I. (2010-03-01). "Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)". Journal of the American Medical Informatics Association 17 (2): 124-130. doi:10.1136/jamia.2009.000893.>
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