Unsolved:Anti-aging movement

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Short description: Social movement devoted to eliminating or reversing aging, or reducing its the effects

The anti-aging movement is a social movement devoted to eliminating or reversing aging, or reducing the effects of it.[1][2] A substantial portion of the attention of the movement is on the possibilities for life extension, but there is also interest in techniques such as cosmetic surgery which ameliorate the effects of aging rather than delay or defeat it.[3]

There are many scientists of this movement with different approaches. Two of the most popular proponents of the anti-aging movement include Ray Kurzweil, who says humanity can defeat aging through the advance of technology,[4] and Aubrey de Grey, who says that the human body is a very complicated machine and, thus, can be repaired indefinitely.[5] Other scientists and significant contributors to the movement include molecular biologists, geneticists, and biomedical gerontologists such as Gary Ruvkun, Cynthia Kenyon, and Arthur D. Levinson. However, figures in the gerontology community in 2003 tried to distance their research from the perceived pseudoscience of the movement.[6]

Anti-aging medicine

Anti-aging medicine has become a budding and rapidly growing medical specialty as physicians who initially sought treatment for themselves have received training and certification in its practice[1] by organizations such as the American Academy of Anti-Aging Medicine (A4M) co-founded by Dr Robert M. Goldman and Ronald Klatz.

Human growth hormone

Central to anti-aging medicine is administration of human growth hormone.[7] Clinical studies have shown that low-dose growth hormone (GH) treatment for adults with GH deficiency changes the body composition by increasing muscle mass, decreasing fat mass, and increasing bone density and muscle strength. It also improves cardiovascular parameters (i.e. decrease of LDL cholesterol) and affects the quality of life without significant side effects.[8][9][10] However, it is also said to have potentially dangerous side effects when used in injectable form, if proper protocols are not followed. It is not approved for use in healthy aging patients, though the restriction is occasionally sidestepped by means of a diagnosis of some injury, organic condition, or adult growth hormone deficiency[11] which supposedly has resulted in reduced secretion of the hormone.[12]

Menopausal hormone drugs

Administration of estrogen and other hormones such as progestin were popularized by the 1966 book Feminine Forever by Robert A. Wilson.[13] However, the increase of the use of estrogen was shown to be associated with an increased risk of cancer.[14] Later, in 2002, research into the long-term effects of estrogen on post-menopausal women, the Women's Health Initiative, produced evidence that there were serious side effects.[15] Physicians who prescribe the hormones now prescribe low doses of the drugs. Research into the long-term effects of hormone replacement therapy is continuing, with a 2017 Cochrane systematic review concluding that long-term use may decrease the risk of bone fractures or postmenopausal osteoporosis, but increase the risk of stroke, heart attacks, endometrial cancer, and breast cancer.[16] Hormone therapy is generally only recommended for postmenopausal women who are at a high risk of osteoporosis when non-hormonal treatments are not suitable.[16] Hormone therapy is not suitable or advised for treating cardiovascular disease, dementia, or for preventing cognitive decline in postmenopausal women.[16] The risks of long-term hormonal therapy for women under 50 years of age have not been determined.[16]

Senolytics

This section is an excerpt from Senolytic[ edit ]

Scientific approaches

Biogerontology is a scientific discipline which has the same area of interest but, as a branch of gerontology, takes a more conservative approach.[17] Caloric restriction is a phenomenon introduced in anti-aging techniques which focuses on depletion of calories and taking the right amount of nutrients necessary for growth.[18]

Calorie restriction

Calorie restriction (CR) refers to a dietary restriction that focuses on less calorie intake to increase longevity and reduce age-related disease in humans. Calorie restriction maintains a low calorie intake that helps to regulate the rate of aging and increases the youthfulness of an individual or animal.[19] Low calorie intake has directly been correlated to negative energy balance which promotes low body mass index (BMI) and comparatively high plasma dehydroepiandrosterone (DHEA) for improved life expectancy.[20] Calorie restriction has widely been practiced by pregnant women and people with pre-existing medical conditions such as diabetes. The right amount of calorie restriction help pregnant women to achieve positive weight gain whereas a significant drop in calorie intake can lead to hypothalamic alterations leading to long-term effects in the offspring.[21] Moderate CR in diabetic patients increases insulin sensitivity and reduces the amount of hepatic fat in obese individual and type 2 diabetes.[22] Long term CR in older animals results in stem cell function similar to that of the younger groups. The active stem cell function helps in enhanced recovery of the damaged skeletal muscle tissue, which is slower in older individuals compared to younger individuals.[23] CR in the United States has shown a prolonged life span in women compared to men as women tend to consume 25% fewer calories than men in their lifetime.[24] The statistical analysis of CR available for anti-aging movement in humans is not sufficient enough to prove the prolonged lifespan associated with CR.

Mass movement

A substantial fraction of older people, taking their cue from alternative medicine, purchase and use herbal supplements and other products which promise relief from the incidents and dangers of aging. However, many such products are unregulated, and can instead pose serious health risks.[25]

Reception

There are at least two opposite views on the prospects of anti-aging research and development. One group states that there is a great deal of over-heated rhetoric in use with respect to life extension with over-optimistic projections by its advocates. They also claim that there is little evidence that any significant breakthrough has been made, or is on the horizon.[26] Some state that this is largely due to a current lack of funding or interest in the issue.[27] A study of the commonly-used supplements and hormone treatments published in 2006 in the Cleveland Clinic Journal of Medicine showed that none of them are effective for extending life.[28] Another group notices that recent scientific successes in rejuvenation and extending the lifespan of model animals[29][failed verification] and discovery of a variety of species (including humans of advanced ages) having negligible senescence give hope to achieve negligible senescence (cancel aging) for younger humans, reverse ageing, or at least significantly delay it.

Though some scientists think curing aging is impossible, there are some criticisms of both the time frame life extensionists envision (the first, perhaps somewhat crude, treatments within the next several decades, or at least before the beginning of the 22nd century) and of whether curing aging is even desirable. Common criticisms of the idea of life extension are fears it will cause the world to be more overpopulated; however, de Grey counters that by saying that since menopause would also be delayed, women could wait longer to have children and, thus, the rate of growth would actually decline as a result. Also, the slowly growing population would buy centuries of time to figure out new places to live, such as space colonies.[30]

See also


References

  1. ↑ 1.0 1.1 Mykytyn, Courtney Everts (February 2006). "Anti-aging medicine: A patient/practitioner movement to redefine aging". Social Science & Medicine 62 (3): 643–653. doi:10.1016/j.socscimed.2005.06.021. ISSN 0277-9536. PMID 16040177. 
  2. ↑ Vincent, John (2013). "The Anti-Aging Movement". in Schermer, Maartje; Pinxten, Wim. Ethics, Health Policy and (Anti-) Aging: Mixed Blessings. Springer Netherlands. p. 30. ISBN 978-94-007-3870-6. "There have been a number of social movements associated with the reappraisal of age-based social categories in the last thirty years. Two such developments are the focus of this chapter. They are the Third Age movement and the Anti-aging movement. These movements present contrasting perspectives on the culturally devalued status of old age; the former seeks to celebrate old age, the latter to eliminate it." 
  3. ↑ Landman, Beth (12 December 2016). "The Future of Forever Young: 12 of the Latest Anti-Aging Treatments You Can Now Try". The Hollywood Reporter. http://www.hollywoodreporter.com/lists/future-forever-young-12-latest-anti-aging-treatments-you-can-try-952805. 
  4. ↑ Hamilton, Craig. "Chasing Immortality—The Technology of Eternal Life". EnlightenNext. http://www.enlightennext.org/magazine/j30/kurzweil.asp. 
  5. ↑ "Who is Aubrey de Grey?". http://www.singularitysymposium.com/aubrey-de-grey.html. "Maybe it is because of his background in computer science that Dr. de Grey perceives the human body as a very complicated machine. Therefore, he argues that aging is primarily an engineering problem. Thus once we grasp all the finer details of our biological structure then the problem of aging becomes one of maintenance and just like today we are capable to maintain vintage cars or airplanes indefinitely he believes that eventually we'll be able to do so with our bodies." 
  6. ↑ Binstock, Robert (2003). "The War on "Anti-Aging Medicine"". The Gerontologist 43 (1): 4–14. doi:10.1093/geront/43.1.4. PMID 12604740. "Leading members of the gerontological community have recently launched a war on anti-aging medicine, seeking to discredit what they judge to be fraudulent and harmful products and therapies, and to distinguish their research from what they regard as the pseudoscience of the anti-aging movement.". 
  7. ↑ Ronald Klatz, Grow Young with HGH: The Amazing Medically Proven Plan to Reverse Aging Harper Paperbacks (May 8, 1998), trade paperback, 400 pages ISBN:0-06-098434-1 ISBN:978-0060984342
  8. ↑ "Treatment of adult growth hormone deficiency: who, why and how? A review". Acta Clinica Belgica 65 (1): 13–22. 2010. doi:10.1179/acb.2010.002. PMID 20373593. 
  9. ↑ "Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement". Clinical Endocrinology 54 (6): 709–17. June 2001. doi:10.1046/j.1365-2265.2001.01275.x. PMID 11422104. 
  10. ↑ "Growth hormone - hormone replacement for the somatopause?". Hormone Research 53 (Suppl 3): 37–41. 2000. doi:10.1159/000023531. PMID 10971102. 
  11. ↑ "Selling The Promise Of Youth" cover story Business Week March 20, 2006
  12. ↑ Wilson, Duff (April 15, 2007). "Aging: Disease or Business Opportunity?". The New York Times. https://www.nytimes.com/2007/04/15/business/yourmoney/15aging.html. 
  13. ↑ Robert A. Wilson, Feminine Forever, M. Evans and Company, Inc. (June 15, 1968), hardcover, ISBN:0-87131-049-X ISBN:978-0871310491
  14. ↑ H Jick; A M Walker; K J Rothman (March 1980). "The epidemic of endometrial cancer: a commentary". American Journal of Public Health 70 (3): 264–267. doi:10.2105/AJPH.70.3.264. PMID 7356090. 
  15. ↑ "Findings from the WHI Postmenopausal Hormone Therapy Trials". National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/whi/. 
  16. ↑ 16.0 16.1 16.2 16.3 Marjoribanks, Jane; Farquhar, Cindy; Roberts, Helen; Lethaby, Anne; Lee, Jasmine (2017). "Long-term hormone therapy for perimenopausal and postmenopausal women". The Cochrane Database of Systematic Reviews 1 (1): CD004143. doi:10.1002/14651858.CD004143.pub5. ISSN 1469-493X. PMID 28093732. 
  17. ↑ Fishman, Jennifer R. (2008). "Anti-aging science: The emergence, maintenance, and enhancement of a discipline". Journal of Aging Studies 22 (4): 295–303. doi:10.1016/j.jaging.2008.05.010. PMID 23264719. 
  18. ↑ Everitt, Arthur V.; Couteur, DAVID G. Le (2007). "Life Extension by Calorie Restriction in Humans" (in en). Annals of the New York Academy of Sciences 1114 (1): 428–433. doi:10.1196/annals.1396.005. ISSN 1749-6632. PMID 17717102. Bibcode: 2007NYASA1114..428E. 
  19. ↑ Sohal, Rajindar S.; Forster, Michael J. (2014-08-01). "Caloric restriction and the aging process: a critique" (in en). Free Radical Biology and Medicine 73: 366–382. doi:10.1016/j.freeradbiomed.2014.05.015. ISSN 0891-5849. PMID 24941891. 
  20. ↑ Bj, Willcox; Dc, Willcox; H, Todoriki; A, Fujiyoshi; K, Yano; Q, He; Jd, Curb; M, Suzuki (October 2007). "Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging: The Diet of the World's Longest-Lived People and Its Potential Impact on Morbidity and Life Span" (in en). Annals of the New York Academy of Sciences 1114 (1): 434–455. doi:10.1196/annals.1396.037. PMID 17986602. Bibcode: 2007NYASA1114..434W. 
  21. ↑ Ramírez-López, María Teresa; Vázquez, Mariam; Bindila, Laura; Lomazzo, Ermelinda; Hofmann, Clementine; Blanco, Rosarío Noemí; Alén, Francisco; Antón, María et al. (2016-11-01). "Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring". Frontiers in Behavioral Neuroscience 10: 208. doi:10.3389/fnbeh.2016.00208. ISSN 1662-5153. PMID 27847471. 
  22. ↑ Larson-Meyer, D. Enette; Heilbronn, Leonie K.; Redman, Leanne M.; Newcomer, Bradley R.; Frisard, Madlyn I.; Anton, Steve; Smith, Steven R.; Alfonso, Anthony et al. (2006-06-01). "Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects" (in en). Diabetes Care 29 (6): 1337–1344. doi:10.2337/dc05-2565. ISSN 0149-5992. PMID 16732018. 
  23. ↑ Cerletti, Massimiliano; Jang, Young C.; Finley, Lydia W.S.; Haigis, Marcia C.; Wagers, Amy J. (2012-05-04). "Short-term calorie restriction enhances skeletal muscle stem cell function". Cell Stem Cell 10 (5): 515–519. doi:10.1016/j.stem.2012.04.002. ISSN 1934-5909. PMID 22560075. 
  24. ↑ Everitt, Arthur V.; Le Couteur, David G. (October 2007). "Life extension by calorie restriction in humans". Annals of the New York Academy of Sciences 1114 (1): 428–433. doi:10.1196/annals.1396.005. ISSN 0077-8923. PMID 17717102. Bibcode: 2007NYASA1114..428E. 
  25. ↑ 'Health Products for Seniors: "Anti-Aging" Products Pose Danger for Physical and Economic Harm' report by the GAO September, 2001
  26. ↑ Turner, Leigh (2004). "Biotechnology, bioethics and anti-aging interventions". Trends in Biotechnology 22 (5): 219–221. doi:10.1016/j.tibtech.2004.03.008. PMID 15109806. 
  27. ↑ Pelletier, Dick. "Advances in medical technologies predicted for this decade". Positive Futurist. http://positivefuturist.com/archive/368.html. 
  28. ↑ Kamel, Nabil S; Julie Gammack; Oscar Cepeda; Joseph H Flaherty (2006). "Antioxidants and hormones as antiaging therapies: high hopes, disappointing results". Cleveland Clinic Journal of Medicine 73 (12): 1049–1056, 1058. doi:10.3949/ccjm.73.12.1049. ISSN 0891-1150. PMID 17190308. 
  29. ↑ "Scientists' Open Letter on Aging Research". CureAging.org: Independent Open Letter in Support of Aging Research. http://www.imminst.org/cureaging/. 
  30. ↑ Gavrilov, Leonid A.; Gavrilova, Natalia S. (April 2010). "Demographic Consequences of Defeating Aging". Rejuvenation Research 13 (2–3): 329–334. doi:10.1089/rej.2009.0977. PMID 20426616. 

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