View source for Physics:Screened Coulomb potentials implicit solvent model

{{Short description | Continuum solvent model for biomolecular simulations}}

'''SCP-ISM''', or '''screened Coulomb potentials implicit solvent model''', is a continuum approximation of [[Physics:Solvent|solvent]] effects for use in computer simulations of [[Biology:Biology|biological]] [[Biology:Macromolecule|macromolecule]]s, such as [[Biology:Protein|protein]]s and [[Biology:Nucleic acid|nucleic acid]]s, usually within the framework of [[Physics:Molecular dynamics|molecular dynamics]]. It is based on the classic theory of [[Physics:Intermolecular force|polar liquid]]s, as developed by [[Biography:Peter Debye|Peter Debye]] and corrected by [[Biography:Lars Onsager|Lars Onsager]] to incorporate reaction field effects. The model can be combined with [[Chemistry:Quantum chemistry|quantum chemical]] calculations to formally derive a continuum model of solvent effects suitable for computer simulations of small and large molecular systems. 

== External links ==
* [https://web.archive.org/web/20041023103224/http://cmm.cit.nih.gov/~mago/scpism-qualitative.html An essay on SCP-ISM]
* [http://www.charmm.org CHARMM website]

[[Category:Molecular dynamics]]


{{Sourceattribution|Screened Coulomb potentials implicit solvent model}}