Biology:CDGSH iron sulfur domain
From HandWiki
Short description: Protein domain
| CDGSH iron sulfur domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| Symbol | CDGSH | ||||||||
| Pfam | PF10660 | ||||||||
| InterPro | IPR019610 | ||||||||
| Membranome | 212 | ||||||||
| |||||||||
| CDGSH iron sulfur domain 1 | |
|---|---|
| Identifiers | |
| Symbol | CISD1 |
| Alt. symbols | C10orf70, ZCD1 |
| NCBI gene | 55847 |
| HGNC | 30880 |
| PDB | 2QH7 |
| RefSeq | NM_018464 |
| UniProt | Q9NZ45 |
| Other data | |
| Locus | Chr. 10 q21.3 |
| CDGSH iron sulfur domain 2 | |
|---|---|
| Identifiers | |
| Symbol | CISD2 |
| Alt. symbols | ZCD2 |
| NCBI gene | 493856 |
| HGNC | 24212 |
| RefSeq | NM_001008388 |
| UniProt | Q7Z3D5 |
| Other data | |
| Locus | Chr. 4 q24 |
| CDGSH iron sulfur domain 3 | |
|---|---|
| Identifiers | |
| Symbol | CISD3 |
| NCBI gene | 284106 |
| HGNC | 27578 |
| Other data | |
| Locus | Chr. 17 q12 |
The CDGSH iron sulfur domain are a group of iron-sulfur (2Fe-2S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].
The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.[1] Iron in turn is essential for the function of several mitochondrial enzymes.
The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.[2]
References
- ↑ "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14342–7. 2007. doi:10.1073/pnas.0707189104. PMID 17766440. Bibcode: 2007PNAS..10414342P.
- ↑ "Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe". Am. J. Physiol. Endocrinol. Metab. 286 (2): E252–60. 2004. doi:10.1152/ajpendo.00424.2003. PMID 14570702.
External links
- ZCD1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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