Biology:ADAMTS10
Generic protein structure example |
A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[1]
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[1]
References
Further reading
- Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases.". Int. J. Biochem. Cell Biol. 33 (1): 33–44. doi:10.1016/S1357-2725(00)00061-3. PMID 11167130.
- "Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome.". Am. J. Med. Genet. A 123 (2): 204–7. 2004. doi:10.1002/ajmg.a.20289. PMID 14598350.
- Apte SS (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.". Int. J. Biochem. Cell Biol. 36 (6): 981–5. doi:10.1016/j.biocel.2004.01.014. PMID 15094112.
- "Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.". Hum. Genet. 110 (4): 366–70. 2002. doi:10.1007/s00439-002-0689-3. PMID 11941487.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197.
- "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. 2005. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
- "Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation.". J. Biol. Chem. 279 (49): 51208–17. 2005. doi:10.1074/jbc.M409036200. PMID 15355968.
- "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G346–53. 2005. doi:10.1152/ajpgi.00262.2004. PMID 15358598.
- "ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome.". Am. J. Hum. Genet. 75 (5): 801–6. 2005. doi:10.1086/425231. PMID 15368195.
External links
- GeneReviews/NIH/NCBI/UW entry on Weill-Marchesani Syndrome
- The MEROPS online database for peptidases and their inhibitors: M12.235
- Human ADAMTS10 genome location and ADAMTS10 gene details page in the UCSC Genome Browser.
Original source: https://en.wikipedia.org/wiki/ADAMTS10.
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