Biology:ADAMTS10

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.

Further reading

• Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases.". Int. J. Biochem. Cell Biol. 33 (1): 33–44. doi:10.1016/S1357-2725(00)00061-3. PMID 11167130. 
• "Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome.". Am. J. Med. Genet. A 123 (2): 204–7. 2004. doi:10.1002/ajmg.a.20289. PMID 14598350. 
• Apte SS (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.". Int. J. Biochem. Cell Biol. 36 (6): 981–5. doi:10.1016/j.biocel.2004.01.014. PMID 15094112. 
• "Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.". Hum. Genet. 110 (4): 366–70. 2002. doi:10.1007/s00439-002-0689-3. PMID 11941487. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197. 
• "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. 2005. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218. 
• "Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation.". J. Biol. Chem. 279 (49): 51208–17. 2005. doi:10.1074/jbc.M409036200. PMID 15355968. 
• "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G346–53. 2005. doi:10.1152/ajpgi.00262.2004. PMID 15358598. 
• "ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome.". Am. J. Hum. Genet. 75 (5): 801–6. 2005. doi:10.1086/425231. PMID 15368195. 

External links

• GeneReviews/NIH/NCBI/UW entry on Weill-Marchesani Syndrome
• The MEROPS online database for peptidases and their inhibitors: M12.235
• Human ADAMTS10 genome location and ADAMTS10 gene details page in the UCSC Genome Browser.