Biology:MAPK8IP3
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C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.[1][2][3]
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]
Interactions
MAPK8IP3 has been shown to interact with ASK1,[4] C-Raf,[1][5] PTK2,[6] MAPK10,[1][2][4] Mitogen-activated protein kinase 9,[1][2] MAPK8,[1][2] MAP2K1,[1][5] KLC2,[7] MAP2K7,[2][4] KLC1,[7] MAPK8IP2[2] and MAP2K4.[1][4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol Cell Biol 19 (11): 7539–48. November 1999. doi:10.1128/mcb.19.11.7539. PMID 10523642.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol 20 (3): 1030–43. February 2000. doi:10.1128/MCB.20.3.1030-1043.2000. PMID 10629060.
- ↑ 3.0 3.1 "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23162.
- ↑ 4.0 4.1 4.2 4.3 Matsuura, Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. (United States) 277 (43): 40703–9. doi:10.1074/jbc.M202004200. ISSN 0021-9258. PMID 12189133.
- ↑ 5.0 5.1 Kuboki, Y; Ito M; Takamatsu N; Yamamoto K I; Shiba T; Yoshioka K (December 2000). "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways". J. Biol. Chem. (UNITED STATES) 275 (51): 39815–8. doi:10.1074/jbc.C000403200. ISSN 0021-9258. PMID 11044439.
- ↑ Takino, Takahisa; Yoshioka Katsuji; Miyamori Hisashi; Yamada Kenneth M; Sato Hiroshi (September 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated". Oncogene (England) 21 (42): 6488–97. doi:10.1038/sj.onc.1205840. ISSN 0950-9232. PMID 12226752.
- ↑ 7.0 7.1 Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell (UNITED STATES) 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. ISSN 0092-8674. PMID 11106729.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. 1999. doi:10.1093/dnares/6.3.197. PMID 10470851.
- "A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways.". J. Biol. Chem. 275 (51): 39815–8. 2001. doi:10.1074/jbc.C000403200. PMID 11044439.
- "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.". Cell 103 (4): 583–94. 2001. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729.
- "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. 2001. doi:10.1093/hmg/10.4.339. PMID 11157797.
- "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. 2001. doi:10.1093/dnares/7.6.357. PMID 11214971.
- "Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system.". Neurosci. Res. 39 (4): 391–400. 2001. doi:10.1016/S0168-0102(01)00194-8. PMID 11274738.
- "UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.". Neuron 32 (5): 787–800. 2002. doi:10.1016/S0896-6273(01)00532-3. PMID 11738026.
- "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.". J. Biol. Chem. 277 (43): 40703–9. 2002. doi:10.1074/jbc.M202004200. PMID 12189133.
- "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated.". Oncogene 21 (42): 6488–97. 2002. doi:10.1038/sj.onc.1205840. PMID 12226752.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress.". Mol. Cell. Biochem. 262 (1–2): 71–8. 2005. doi:10.1023/B:MCBI.0000038218.09259.1c. PMID 15532711.
- "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. 2005. doi:10.1038/nature03187. PMID 15616553. Bibcode: 2004Natur.432..988M.
- "Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators.". J. Biol. Chem. 280 (29): 26845–55. 2005. doi:10.1074/jbc.M502318200. PMID 15911620.
- "JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration.". J. Biol. Chem. 280 (45): 37772–81. 2006. doi:10.1074/jbc.M505241200. PMID 16141199.
- "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674.
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