Biology:MAPK10
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Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.[1][2][3]
Function
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
MAPK10 has been shown to interact with MAPK8IP3.[4][5][6]
References
- ↑ "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. July 1996. doi:10.1002/j.1460-2075.1996.tb00636.x. PMID 8654373.
- ↑ "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J. Hum. Genet. 47 (11): 614–9. November 2002. doi:10.1007/s100380200094. PMID 12436199.
- ↑ 3.0 3.1 "Entrez Gene: MAPK10 mitogen-activated protein kinase 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5602.
- ↑ "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. November 1999. doi:10.1128/mcb.19.11.7539. PMID 10523642.
- ↑ "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. February 2000. doi:10.1128/MCB.20.3.1030-1043.2000. PMID 10629060.
- ↑ "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. October 2002. doi:10.1074/jbc.M202004200. PMID 12189133.
Further reading
- "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunol. Res. 27 (2–3): 261–76. 2003. doi:10.1385/IR:27:2-3:261. PMID 12857973.
- "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. 2003. doi:10.1189/jlb.0503206. PMID 12960231.
- "Phosphorylation of c-jun mediated by MAP kinases". Nature 353 (6345): 670–4. 1991. doi:10.1038/353670a0. PMID 1922387. Bibcode: 1991Natur.353..670P.
- "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system". Neuron 14 (1): 67–78. 1995. doi:10.1016/0896-6273(95)90241-4. PMID 7826642.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". Eur. J. Immunol. 27 (2): 397–404. 1997. doi:10.1002/eji.1830270209. PMID 9045910.
- "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature 389 (6653): 865–70. 1997. doi:10.1038/39899. PMID 9349820. Bibcode: 1997Natur.389..865Y.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene 15 (19): 2277–87. 1997. doi:10.1038/sj.onc.1201401. PMID 9393873.
- "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Ann. Neurol. 42 (6): 847–56. 1997. doi:10.1002/ana.410420605. PMID 9403476.
- "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis". Structure 6 (8): 983–91. 1998. doi:10.1016/S0969-2126(98)00100-2. PMID 9739089.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1". FEBS Lett. 457 (3): 385–8. 1999. doi:10.1016/S0014-5793(99)01084-4. PMID 10471813.
- "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. 1999. doi:10.1128/mcb.19.11.7539. PMID 10523642.
- "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. 2000. doi:10.1128/MCB.20.3.1030-1043.2000. PMID 10629060.
- "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1". Biochemistry 39 (11): 3141–8. 2000. doi:10.1021/bi992410. PMID 10715136.
- "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science 290 (5496): 1574–7. 2000. doi:10.1126/science.290.5496.1574. PMID 11090355. Bibcode: 2000Sci...290.1574M.
- "Signal transduction. An arresting start for MAPK". Science 290 (5496): 1515–8. 2000. doi:10.1126/science.290.5496.1515. PMID 11185509.
- "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation". Nat. Cell Biol. 3 (3): 325–30. 2001. doi:10.1038/35060131. PMID 11231586.
External links
- MAP Kinase Resource .
- Overview of all the structural information available in the PDB for UniProt: P53779 (Mitogen-activated protein kinase 10) at the PDBe-KB.
![]() | Original source: https://en.wikipedia.org/wiki/MAPK10.
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