Biology:MAPK10

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MAPK10 has been shown to interact with MAPK8IP3.

Further reading

• "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunol. Res. 27 (2–3): 261–76. 2003. doi:10.1385/IR:27:2-3:261. PMID 12857973. 
• "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. 2003. doi:10.1189/jlb.0503206. PMID 12960231. 
• "Phosphorylation of c-jun mediated by MAP kinases". Nature 353 (6345): 670–4. 1991. doi:10.1038/353670a0. PMID 1922387. Bibcode: 1991Natur.353..670P. 
• "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system". Neuron 14 (1): 67–78. 1995. doi:10.1016/0896-6273(95)90241-4. PMID 7826642. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". Eur. J. Immunol. 27 (2): 397–404. 1997. doi:10.1002/eji.1830270209. PMID 9045910. 
• "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature 389 (6653): 865–70. 1997. doi:10.1038/39899. PMID 9349820. Bibcode: 1997Natur.389..865Y. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene 15 (19): 2277–87. 1997. doi:10.1038/sj.onc.1201401. PMID 9393873. 
• "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Ann. Neurol. 42 (6): 847–56. 1997. doi:10.1002/ana.410420605. PMID 9403476. 
• "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis". Structure 6 (8): 983–91. 1998. doi:10.1016/S0969-2126(98)00100-2. PMID 9739089. 
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• "A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1". FEBS Lett. 457 (3): 385–8. 1999. doi:10.1016/S0014-5793(99)01084-4. PMID 10471813. 
• "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. 1999. doi:10.1128/mcb.19.11.7539. PMID 10523642. 
• "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. 2000. doi:10.1128/MCB.20.3.1030-1043.2000. PMID 10629060. 
• "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1". Biochemistry 39 (11): 3141–8. 2000. doi:10.1021/bi992410. PMID 10715136. 
• "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science 290 (5496): 1574–7. 2000. doi:10.1126/science.290.5496.1574. PMID 11090355. Bibcode: 2000Sci...290.1574M. 
• "Signal transduction. An arresting start for MAPK". Science 290 (5496): 1515–8. 2000. doi:10.1126/science.290.5496.1515. PMID 11185509. 
• "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation". Nat. Cell Biol. 3 (3): 325–30. 2001. doi:10.1038/35060131. PMID 11231586. 

External links

• MAP Kinase Resource .
• Overview of all the structural information available in the PDB for UniProt: P53779 (Mitogen-activated protein kinase 10) at the PDBe-KB.