Biology:LLGL1
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Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.[1][2][3]
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[3]
References
- ↑ "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain". Oncogene 11 (2): 291–301. Aug 1995. PMID 7542763.
- ↑ "The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2". Cytogenet Cell Genet 72 (1): 78–82. Mar 1996. doi:10.1159/000134167. PMID 8565641.
- ↑ 3.0 3.1 "Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3996.
Further reading
- "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL.". Genomics 42 (1): 46–54. 1997. doi:10.1006/geno.1997.4709. PMID 9177775.
- "A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization.". J. Biol. Chem. 277 (6): 4477–84. 2002. doi:10.1074/jbc.M108479200. PMID 11714708.
- "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. 2002. doi:10.1101/gr.73702. PMID 11997338.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. 2004. doi:10.1016/S0960-9822(03)00244-6. PMID 12725730.
- "The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo". Oncogene 23 (53): 8688–94. 2004. doi:10.1038/sj.onc.1208023. PMID 15467749.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer". Oncogene 24 (19): 3100–9. 2005. doi:10.1038/sj.onc.1208520. PMID 15735678.
- "Expression of Hugl-1 is strongly reduced in malignant melanoma". Oncogene 25 (1): 103–10. 2006. doi:10.1038/sj.onc.1209008. PMID 16170365.
- "aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia". Oncogene 26 (40): 5960–5. 2007. doi:10.1038/sj.onc.1210389. PMID 17369850.
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