Biology:Beta-thromboglobulin
Beta-thromboglobulin (also known as β-thromboglobulin) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.[1] It is a type of Chemokine (C-X-C motif) ligand 7.[2]
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It is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[1]
Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production.[1]
Clinical use
Levels of Beta-Thromboglobulin is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4)[1]
It is elevated in diabetes mellitus.[3]
References
- ↑ 1.0 1.1 1.2 1.3 Cytokines & Cells Online Pathfinder Encyclopaedia --> Beta-Thromboglobulin Retrieved on August 17, 2009
- ↑ "Monocyte-derived CXCL7 peptides in the marrow microenvironment". Blood 107 (9): 3520–6. May 2006. doi:10.1182/blood-2005-10-4285. PMID 16391012.
- ↑ Page 121 in: Sterne, Jonathan; Kirkwood, Betty R. (2003). Essential medical statistics. Oxford: Blackwell Science. ISBN 0-86542-871-9. https://archive.org/details/essentialmedical00kirk.
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