Biology:CXCL7
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.[1]
The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).[2]
It is a protein that is released in large amounts from platelets following their activation.[3] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.[4][5]
References
- ↑ "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5473.
- ↑ "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. March 2007. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812.
- ↑ "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem 266 (9): 5785–9. 1991. doi:10.1016/S0021-9258(19)67665-9. PMID 1826003.
- ↑ "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA 80 (3): 765–9. 1983. doi:10.1073/pnas.80.3.765. PMID 6572368. Bibcode: 1983PNAS...80..765C.
- ↑ "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry 24 (7): 1762–7. 1985. doi:10.1021/bi00328a029. PMID 4005226.
Further reading
- "Complete covalent structure of human beta-thromboglobulin.". Biochemistry 17 (9): 1739–44. 1978. doi:10.1021/bi00602a024. PMID 77677.
- "Platelet alpha-granule proteins: studies on release and subcellular localization.". Blood 53 (4): 604–18. 1979. doi:10.1182/blood.V53.4.604.604. PMID 426909.
- "Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4.". Blood 79 (11): 2896–900. 1992. doi:10.1182/blood.V79.11.2896.bloodjournal79112896. PMID 1316786.
- "Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.". Am. J. Physiol. 263 (2 Pt 1): L249–56. 1992. doi:10.1152/ajplung.1992.263.2.L249. PMID 1387511.
- "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.". Genomics 14 (3): 685–91. 1992. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.
- "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.". J. Biol. Chem. 266 (9): 5785–9. 1991. doi:10.1016/S0021-9258(19)67665-9. PMID 1826003.
- "Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.". Hum. Genet. 87 (3): 367–8. 1991. doi:10.1007/BF00200921. PMID 1830861.
- "A new assay for beta-thromboglobulin in urine.". Thromb. Res. 64 (1): 33–43. 1992. doi:10.1016/0049-3848(91)90203-9. PMID 1837963.
- "Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.". Cytokine 3 (4): 311–21. 1991. doi:10.1016/1043-4666(91)90499-4. PMID 1873479.
- "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.". Biochemistry 30 (12): 3128–35. 1991. doi:10.1021/bi00226a021. PMID 2007144.
- "Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.". J. Exp. Med. 171 (2): 449–54. 1990. doi:10.1084/jem.171.2.449. PMID 2406364.
- "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.". Biochemistry 25 (8): 1988–96. 1986. doi:10.1021/bi00356a023. PMID 2423119.
- "A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.". Biochem. Biophys. Res. Commun. 159 (3): 969–75. 1989. doi:10.1016/0006-291X(89)92203-1. PMID 2522778.
- "Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.". Blood 73 (6): 1498–503. 1989. doi:10.1182/blood.V73.6.1498.1498. PMID 2713489.
- "Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.". Biochem. Biophys. Res. Commun. 163 (2): 1071–8. 1989. doi:10.1016/0006-291X(89)92330-9. PMID 2783111.
- "Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.". Exp. Hematol. 16 (4): 302–6. 1988. PMID 2966071.
- "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.". Biochemistry 24 (7): 1762–7. 1985. doi:10.1021/bi00328a029. PMID 4005226.
- "Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.". J. Clin. Pathol. 35 (11): 1227–31. 1983. doi:10.1136/jcp.35.11.1227. PMID 6183294.
- "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.". Proc. Natl. Acad. Sci. U.S.A. 80 (3): 765–9. 1983. doi:10.1073/pnas.80.3.765. PMID 6572368. Bibcode: 1983PNAS...80..765C.
- "The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.". J. Biol. Chem. 270 (13): 7077–87. 1995. doi:10.1074/jbc.270.13.7077. PMID 7706245.
External links
- Human PPBP genome location and PPBP gene details page in the UCSC Genome Browser.
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