Biology:PDE6G

Generic protein structure example

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase and Src.

Further reading

• "Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase". Experimental Eye Research 53 (5): 557–64. November 1991. doi:10.1016/0014-4835(91)90213-X. PMID 1683837. 
• "[The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase]". Doklady Akademii Nauk SSSR 315 (1): 229–31. 1991. PMID 1965799. 
• "Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina". Gene 88 (2): 227–32. April 1990. doi:10.1016/0378-1119(90)90035-P. PMID 2161380. 
• "Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells". Gene 151 (1–2): 297–301. December 1994. doi:10.1016/0378-1119(94)90674-2. PMID 7828894. 
• "Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa". Investigative Ophthalmology & Visual Science 35 (3): 1077–82. March 1994. PMID 8125719. 
• "Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25)". Genomics 17 (2): 526–8. August 1993. doi:10.1006/geno.1993.1364. PMID 8406511. 
• "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells". The Journal of Biological Chemistry 276 (41): 37802–8. October 2001. doi:10.1074/jbc.M105087200. PMID 11502744. 
• "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision 8: 196–204. June 2002. PMID 12107411. 
• "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". The Journal of Biological Chemistry 278 (20): 18658–63. May 2003. doi:10.1074/jbc.M212103200. PMID 12624098. 
• "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins". Molecular Vision 9: 449–59. September 2003. PMID 14502124. 
• "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. October 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415-8. January 2006. doi:10.1093/nar/gkj139. PMID 16381901. 

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview