Biology:PDE6G

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.[1][2][3]

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase[4] and Src.[4]

References

  1. "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics 6 (2): 272–83. February 1990. doi:10.1016/0888-7543(90)90567-E. PMID 2155175. 
  2. "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5148. 
  3. "Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances 5 (2): eaav4322. February 2019. doi:10.1126/sciadv.aav4322. PMID 30820458. Bibcode2019SciA....5.4322G. 
  4. 4.0 4.1 "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". The Journal of Biological Chemistry 278 (20): 18658–63. May 2003. doi:10.1074/jbc.M212103200. PMID 12624098. 

Further reading

External links