Biology:CEP250
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene.[1][2][3] This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.[3] Furthermore, CEP135 is also required for the centriolar localization of CEP250.[4]
References
- ↑ "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum 41 (3): 551–8. Apr 1998. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
- ↑ "C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2". J Cell Biol 141 (7): 1563–74. Aug 1998. doi:10.1083/jcb.141.7.1563. PMID 9647649.
- ↑ 3.0 3.1 "Entrez Gene: CEP250 centrosomal protein 250kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11190.
- ↑ "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. December 2008. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962.
External links
- Human CEP250 genome location and CEP250 gene details page in the UCSC Genome Browser.
Further reading
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles". Mol. Biol. Cell 14 (7): 2876–89. 2004. doi:10.1091/mbc.E03-02-0108. PMID 12857871.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles". J. Cell Sci. 115 (Pt 16): 3275–84. 2003. doi:10.1242/jcs.115.16.3275. PMID 12140259. https://resolver.caltech.edu/CaltechAUTHORS:20111031-142910138.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. 2000. doi:10.1083/jcb.151.4.837. PMID 11076968.
- "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J. Biol. Chem. 276 (2): 875–83. 2001. doi:10.1074/jbc.M007039200. PMID 11035016.
- "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1". Biochem. J. 349 (Pt 2): 509–18. 2001. doi:10.1042/0264-6021:3490509. PMID 10880350.
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