Biology:ATP5H
 Generic protein structure example |
| ATP synthase D chain, mitochondrial | |||||||||
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| Identifiers | |||||||||
| Symbol | ATP5H | ||||||||
| Pfam | PF05873 | ||||||||
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The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.[1][2]
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.[2]
References
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. Nov 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ 2.0 2.1 "Entrez Gene: ATP5PD ATP synthase peripheral stalk subunit d". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10476.
External links
- Human ATP5PD genome location and ATP5PD gene details page in the UCSC Genome Browser.
Further reading
- "F1-ATPase: a highly efficient rotary ATP machine.". Essays Biochem. 35: 3–18. 2003. doi:10.1042/bse0350003. PMID 12471886.
- "Rotary protein motors.". Trends Cell Biol. 13 (3): 114–21. 2003. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
- "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review).". Mol. Membr. Biol. 20 (1): 27–33. 2003. doi:10.1080/0968768031000066532. PMID 12745923.
- "The complete amino acid sequence of subunit d of rat liver mitochondrial H(+)-ATP synthase.". J. Biochem. 114 (5): 714–7. 1994. doi:10.1093/oxfordjournals.jbchem.a124242. PMID 7509337.
- "Energy transduction in ATP synthase.". Nature 391 (6666): 510–3. 1998. doi:10.1038/35185. PMID 9461222. Bibcode: 1998Natur.391..510E.
- "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279–82. 1998. doi:10.1038/24409. PMID 9834036. Bibcode: 1998Natur.396..279W.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816. Bibcode: 2004Natur.427..407C.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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