Biology:Mopeia mammarenavirus
| Mopeia mammarenavirus | |
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Virus classification 
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| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Ellioviricetes |
| Order: | Bunyavirales |
| Family: | Arenaviridae |
| Genus: | Mammarenavirus |
| Species: | Mopeia mammarenavirus
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| Strains | |
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| Synonyms | |
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Mopeia virus, MOPV, Mozambique virus, MV | |
Mopeia mammarenavirus (MOPV) is a species of virus in the genus Mammarenavirus.[1] It was initially isolated from the Mastomys natalensis mouse in the East African country of Mozambique in 1977.[2][3][4] It is of the "Old World" Arenavirus lineage and is closely related to Lassa mammarenavirus, sharing 75% of its amino acid sequence.[5][6]
Mopeia virus disease
Mopeia virus has not been known to cause disease in humans, although it is capable of infecting human cell lines in vitro.[7] Infection of primates with the virus was demonstrated to prevent clinical disease following Lassa virus infection, indicating potential for use as a prophylactic vaccine for Lassa Fever.[8]
Geographic distribution
Although initially isolated in Mozambique, it has also been detected in rodents in Zimbabwe,[9] and Tanzania.[4] Although not identified outside of these regions, it is possible that M. natalensis rodents could carry Mopeia virus to other areas of Southeast Africa.[citation needed]
References
- ↑ "Genus: Mammarenavirus - Arenaviridae - Negative-sense RNA Viruses - ICTV". https://talk.ictvonline.org/ictv-reports/ictv_online_report/negative-sense-rna-viruses/w/arenaviridae/1117/genus-mammarenavirus.[|permanent dead link|dead link}}]
- ↑ "Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south-east Africa". Bulletin of the World Health Organization 55 (4): 441–444. 1977. PMID 304387.
- ↑ "Mammarenaviruses of Rodents, South Africa and Zimbabwe". Emerging Infectious Diseases 27 (12): 3092–3102. December 2021. doi:10.3201/eid2712.211088. PMID 34808083.
- ↑ 4.0 4.1 "Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission". Vector Borne and Zoonotic Diseases 11 (8): 1125–1131. August 2011. doi:10.1089/vbz.2010.0010. PMID 21142956.
- ↑ "Arenaviruses". Wildlife and Emerging Zoonotic Diseases: The Biology, Circumstances and Consequences of Cross-Species Transmission. Current Topics in Microbiology and Immunology (Berlin, Heidelberg: Springer Berlin Heidelberg) 315: 253–88. 2007. doi:10.1007/978-3-540-70962-6_11. ISBN 978-3-540-70961-9. PMID 17848068.
- ↑ "Human macrophages, but not dendritic cells, are activated and produce alpha/beta interferons in response to Mopeia virus infection". Journal of Virology 78 (19): 10516–10524. October 2004. doi:10.1128/JVI.78.19.10516-10524.2004. PMID 15367618.
- ↑ "Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission". Vector Borne and Zoonotic Diseases 11 (8): 1125–1131. August 2011. doi:10.1089/vbz.2010.0010. PMID 21142956.
- ↑ "Protection of rhesus monkeys from Lassa virus by immunisation with closely related Arenavirus". Lancet 2 (8145): 738. October 1979. doi:10.1016/s0140-6736(79)90659-7. PMID 90819.
- ↑ "Recovery of a Lassa-related arenavirus in Zimbabwe" (in EN). The American Journal of Tropical Medicine and Hygiene 30 (6): 1291–1293. November 1981. doi:10.4269/ajtmh.1981.30.1291. PMID 7034562.
Wikidata ☰ Q22109872 entry
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