Biology:ALDH1A3
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Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene,[1]
Function
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or a cellular retinol-binding protein form.[2]
Cancer
ALDH1A3 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [3] For this reason, ALDH1A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [3]
References
- ↑ "Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6". Genomics 24 (2): 333–41. November 1994. doi:10.1006/geno.1994.1624. PMID 7698756.
- ↑ "Entrez Gene: ALDH1A3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=220.
- ↑ 3.0 3.1 "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes.". J Cell Physiol 230 (4): 802–812. April 2015. doi:10.1002/jcp.24808. PMID 25205602.
External links
- Human ALDH1A3 genome location and ALDH1A3 gene details page in the UCSC Genome Browser.
Further reading
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Positive association between ALDH1A2 and schizophrenia in the Chinese population.". Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (8): 1491–5. 2009. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR.". Yakugaku Zasshi 122 (5): 339–61. 2002. doi:10.1248/yakushi.122.339. PMID 12040753.
- Gojobori, Takashi, ed (2009). "Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes.". PLOS Genet. 5 (5): e1000496. doi:10.1371/journal.pgen.1000496. PMID 19478994.
- "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.". J. Hum. Genet. 54 (6): 317–23. 2009. doi:10.1038/jhg.2009.31. PMID 19343046.
- "Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells.". Cancer Res. 61 (19): 7065–70. 2001. PMID 11585737.
- "Human aldehyde dehydrogenase gene family.". Eur. J. Biochem. 251 (3): 549–57. 1998. doi:10.1046/j.1432-1327.1998.2510549.x. PMID 9490025.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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