Biology:LIM domain-binding protein family
| LIM-domain binding protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LIM_bind | ||||||||
| Pfam | PF01803 | ||||||||
| InterPro | IPR002691 | ||||||||
| SCOP2 | 1j2o / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, the LIM domain-binding protein family is a family of proteins which binds to the LIM domain of LIM (LIN-11, Isl-1 and MEC-3) homeodomain proteins which are transcriptional regulators of development.
Examples
Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with ISL1 in early motor neuron differentiation and has a suggested role in the ISL1 dependent development of motor neurons.[1] It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development.[2] The Drosophila melanogaster protein Chip is required for segmentation and activity of a remote wing margin enhancer.[3] Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development.[3] It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.[3]
References
- ↑ "Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11693–8. October 1996. doi:10.1073/pnas.93.21.11693. PMID 8876198. Bibcode: 1996PNAS...9311693J.
- ↑ "A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins". Genes Dev. 11 (11): 1370–80. June 1997. doi:10.1101/gad.11.11.1370. PMID 9192866.
- ↑ 3.0 3.1 3.2 "Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila". Genes Dev. 11 (20): 2729–40. October 1997. doi:10.1101/gad.11.20.2729. PMID 9334334.
 |  |
