Template:Relative affinities of hydroxyprogesterone and related steroids

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v · d · e Relative affinities (%) of hydroxyprogesterone and related steroids
Compound hPR-A hPR-B rbPR rbGR rbER
Progesterone 100 100 100 <1 <1
17α-Hydroxyprogesterone 1 1 3 1 <1
Hydroxyprogesterone caproate 26 30 28 4 <1
Hydroxyprogesterone acetate 38 46 115 3 ?
Notes: Values are percentages (%). Reference ligands (100%) were progesterone for the PR, dexamethasone for the GR, and estradiol for the ER. Sources: [1][2]
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References

  1. ↑ "Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins". Am. J. Obstet. Gynecol. 197 (6): 599.e1–7. 2007. doi:10.1016/j.ajog.2007.05.024. PMID 18060946. 
  2. ↑ "Affinities of progestogen and estrogen receptors in rabbit uterus for synthetic progestogens". Steroids 23 (6): 909–919. June 1974. doi:10.1016/0039-128X(74)90063-4. PMID 4134774. 
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