Chemistry:Vapreotide
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Short description: Pharmaceutical drug
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Clinical data | |
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Trade names | Sanvar |
Other names | H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2 Octastatin |
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Pharmacokinetic data | |
Elimination half-life | 30 minutes |
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Chemical and physical data | |
Formula | C57H70N12O9S2 |
Molar mass | 1131.38 g·mol−1 |
3D model (JSmol) | |
Density | 1.4 g/cm3 |
Boiling point | 1,540.9 °C (2,805.6 °F) |
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Vapreotide (Sanvar) is a synthetic somatostatin analog. It is used in the treatment of esophageal variceal bleeding[1][2] in patients with cirrhotic liver disease and AIDS-related diarrhea.[3]
It is an 8 residue peptide with sequence H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2.
References
- ↑ "Vapreotide acetate for the treatment of esophageal variceal bleeding". Expert Review of Gastroenterology & Hepatology 2 (2): 185–92. April 2008. doi:10.1586/17474124.2.2.185. PMID 19072353.
- ↑ "Vapreotide: a somatostatin analog for the treatment of acute variceal bleeding". Expert Opinion on Pharmacotherapy 10 (14): 2337–42. October 2009. doi:10.1517/14656560903207019. PMID 19708854.
- ↑ DrugBank DB04894
![]() | Original source: https://en.wikipedia.org/wiki/Vapreotide.
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