Chemistry:5'-Methoxyhydnocarpin

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5'-Methoxyhydnocarpin
5'-methoxyhydnocarpin.png
Names
IUPAC name
(5′′R,6′′R)-5,7-Dihydroxy-6′′-(4-hydroxy-3-methoxyphenyl)-5′′-(hydroxymethyl)-5′-methoxy-5′′,6′′-dihydro[1,4]dioxino[2′′,3′′:3′,4′]flavone
Systematic IUPAC name
5,7-Dihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl]-4H-1-benzopyran-4-one
Other names
5′-MHC
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
Properties
C26H22O10
Molar mass 494.452 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

5'-Methoxyhydnocarpin (5′-MHC) is a chemical compound that has been isolated from Berberis[1] and Hydnocarpus wightianus.[2]

5′-MHC potentiates the antimicrobial effect of berberine in vitro.[1]

References

  1. 1.0 1.1 Stermitz, F. R.; Lorenz, P; Tawara, J. N.; Zenewicz, L. A.; Lewis, K. (February 15, 2000). "Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor". Proceedings of the National Academy of Sciences (National Academy of Sciences) 97 (4): 1433–1437. doi:10.1073/pnas.030540597. ISSN 1091-6490. PMID 10677479. Bibcode2000PNAS...97.1433S. 
  2. Williams, Cheryll (2013). Medicinal Plants in Australia Volume 4: An Antipodean Apothecary. Rosenberg Publishing. p. 171. ISBN 978-1-925078-08-4. https://books.google.com/books?id=7eVUAQAAQBAJ&q=5%27-Methoxyhydnocarpin+hydnocarpus&pg=PA171.