Biology:CABIN1

Generic protein structure example

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.

Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.

Interactions

CABIN1 has been shown to interact with:

• Amphiphysin,
• MEF2B,
• MEF2D, and
• SIN3A.

Further reading

• "Endogenous protein inhibitors of calcineurin". Biochemical and Biophysical Research Communications 311 (4): 1103–9. Nov 2003. doi:10.1016/j.bbrc.2003.10.020. PMID 14623296. 
• "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell 89 (3): 349–56. May 1997. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134. 
• "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science 286 (5440): 790–3. Oct 1999. doi:10.1126/science.286.5440.790. PMID 10531067. 
• "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. Dec 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D. 
• "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry 275 (29): 22563–7. Jul 2000. doi:10.1074/jbc.C000304200. PMID 10825153. 
• "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry 275 (44): 34017–20. Nov 2000. doi:10.1074/jbc.C000429200. PMID 10931822. 
• "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity 13 (1): 85–94. Jul 2000. doi:10.1016/S1074-7613(00)00010-8. PMID 10933397. 
• "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". The Journal of Experimental Medicine 194 (10): 1449–59. Nov 2001. doi:10.1084/jem.194.10.1449. PMID 11714752. 
• "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature 422 (6933): 730–4. Apr 2003. doi:10.1038/nature01555. PMID 12700764. Bibcode: 2003Natur.422..730H. 
• "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis". Cell 116 (1): 51–61. Jan 2004. doi:10.1016/S0092-8674(03)01064-X. PMID 14718166. 
• "The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT". The Journal of Biological Chemistry 280 (11): 9980–4. Mar 2005. doi:10.1074/jbc.C400401200. PMID 15671033. 
• "Selection of choriocarcinoma-associated genes using bioinformatics". Di 1 Jun Yi da Xue Xue Bao = Academic Journal of the First Medical College of PLA 25 (1): 1–6. Jan 2005. PMID 15683985. 
• "Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation". The EMBO Journal 24 (12): 2104–13. Jun 2005. doi:10.1038/sj.emboj.7600685. PMID 15902271. 
• "A new calcineurin inhibition domain in Cabin1". Biochemical and Biophysical Research Communications 359 (1): 129–35. Jul 2007. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200. 

External links

• Human CABIN1 genome location and CABIN1 gene details page in the UCSC Genome Browser.
• Human KB-318B8.7 genome location and KB-318B8.7 gene details page in the UCSC Genome Browser.