Biology:SIN3A
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.[1][2]
Function
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.[3]
Interactions
SIN3A has been shown to interact with:
- CABIN1[4]
- HBP1,[5]
- HDAC1,[6][7][8][9][10][11][12][13][14][15][16][17][18][19]
- HDAC9,[20][21]
- Histone deacetylase 2,[6][8][9][14][15][22][23]
- Host cell factor C1,[24][25]
- IKZF1,[20][26][27]
- ING1,[19]
- KLF11,[28][29]
- MNT,[30]
- MXD1,[5][31][32]
- Methyl-CpG-binding domain protein 2,[33]
- Nuclear receptor co-repressor 2,[18][34]
- OGT,[35]
- PHF12,[36]
- Promyelocytic leukemia protein,[37]
- RBBP4,[38][39]
- RBBP7,[19][39]
- SAP130,[8]
- SAP30,[8][13][19][36][39][40]
- SMARCA2,[41]
- SMARCA4,[19][41]
- SMARCC1,[19][41]
- SUDS3,[8][42]
- TAL1,[43] and
- Zinc finger and BTB domain-containing protein 16.[44][45][46]
See also
References
- ↑ "Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2". Nucleic Acids Research 28 (10): 2201–6. May 2000. doi:10.1093/nar/28.10.2201. PMID 10773092.
- ↑ "A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3". Genomics 26 (2): 403–6. March 1995. doi:10.1016/0888-7543(95)80229-F. PMID 7601471.
- ↑ "Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25942.
- ↑ "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity 13 (1): 85–94. July 2000. doi:10.1016/S1074-7613(00)00010-8. PMID 10933397.
- ↑ 5.0 5.1 "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nature Structural & Molecular Biology 11 (8): 738–46. August 2004. doi:10.1038/nsmb798. PMID 15235594.
- ↑ 6.0 6.1 "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology 85 (2–5): 401–14. June 2003. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729. https://zenodo.org/record/1260176.
- ↑ "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry 278 (43): 42560–8. October 2003. doi:10.1074/jbc.M302955200. PMID 12920132.
- ↑ 8.0 8.1 8.2 8.3 8.4 "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology 23 (10): 3456–67. May 2003. doi:10.1128/MCB.23.10.3456-3467.2003. PMID 12724404.
- ↑ 9.0 9.1 "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal 369 (Pt 3): 651–7. February 2003. doi:10.1042/BJ20020854. PMID 12398767.
- ↑ "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America 96 (9): 4868–73. April 1999. doi:10.1073/pnas.96.9.4868. PMID 10220385. Bibcode: 1999PNAS...96.4868G.
- ↑ "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell 9 (3): 611–23. March 2002. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
- ↑ "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America 98 (4): 1454–8. February 2001. doi:10.1073/pnas.98.4.1454. PMID 11171972. Bibcode: 2001PNAS...98.1454Y.
- ↑ 13.0 13.1 "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development 13 (15): 1924–35. August 1999. doi:10.1101/gad.13.15.1924. PMID 10444591.
- ↑ 14.0 14.1 "Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex". The Journal of Biological Chemistry 277 (36): 33431–8. September 2002. doi:10.1074/jbc.M204417200. PMID 12091390.
- ↑ 15.0 15.1 "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature 395 (6705): 917–21. October 1998. doi:10.1038/27699. PMID 9804427. Bibcode: 1998Natur.395..917T.
- ↑ "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proceedings of the National Academy of Sciences of the United States of America 95 (7): 3519–24. March 1998. doi:10.1073/pnas.95.7.3519. PMID 9520398. Bibcode: 1998PNAS...95.3519H.
- ↑ "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. October 2002. doi:10.1038/nature01084. PMID 12374985. Bibcode: 2002Natur.419..641Y. https://digital.library.unt.edu/ark:/67531/metadc733622/.
- ↑ 18.0 18.1 "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes & Development 14 (1): 45–54. January 2000. doi:10.1101/gad.14.1.45. PMID 10640275.
- ↑ 19.0 19.1 19.2 19.3 19.4 19.5 "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology 22 (3): 835–48. February 2002. doi:10.1128/MCB.22.3.835-848.2002. PMID 11784859.
- ↑ 20.0 20.1 "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression". The Journal of Biological Chemistry 277 (26): 23143–9. June 2002. doi:10.1074/jbc.M202079200. PMID 11959865.
- ↑ "The histone deacetylase 9 gene encodes multiple protein isoforms". The Journal of Biological Chemistry 278 (18): 16059–72. May 2003. doi:10.1074/jbc.M212935200. PMID 12590135.
- ↑ "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry 278 (9): 7234–9. February 2003. doi:10.1074/jbc.M208992200. PMID 12493763.
- ↑ "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell 89 (3): 349–56. May 1997. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134.
- ↑ "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology 24 (13): 5639–49. July 2004. doi:10.1128/MCB.24.13.5639-5649.2004. PMID 15199122.
- ↑ "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development 17 (7): 896–911. April 2003. doi:10.1101/gad.252103. PMID 12670868.
- ↑ "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. June 1999. doi:10.1093/emboj/18.11.3090. PMID 10357820.
- ↑ "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry 277 (31): 27697–705. August 2002. doi:10.1074/jbc.M201694200. PMID 12015313.
- ↑ "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A". Molecular and Cellular Biology 21 (15): 5041–9. August 2001. doi:10.1128/MCB.21.15.5041-5049.2001. PMID 11438660.
- ↑ "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor". The EMBO Journal 21 (10): 2451–60. May 2002. doi:10.1093/emboj/21.10.2451. PMID 12006497.
- ↑ "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal 16 (10): 2892–906. May 1997. doi:10.1093/emboj/16.10.2892. PMID 9184233.
- ↑ "Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex". Cell 103 (4): 655–65. November 2000. doi:10.1016/S0092-8674(00)00168-9. PMID 11106735.
- ↑ "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell 80 (5): 767–76. March 1995. doi:10.1016/0092-8674(95)90355-0. PMID 7889570.
- ↑ "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A". The Journal of Biological Chemistry 275 (45): 34963–7. November 2000. doi:10.1074/jbc.M005929200. PMID 10950960.
- ↑ "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". The EMBO Journal 19 (16): 4342–50. August 2000. doi:10.1093/emboj/19.16.4342. PMID 10944117.
- ↑ "Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression". Cell 110 (1): 69–80. July 2002. doi:10.1016/S0092-8674(02)00810-3. PMID 12150998.
- ↑ 36.0 36.1 "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology 21 (13): 4110–8. July 2001. doi:10.1128/MCB.21.13.4110-4118.2001. PMID 11390640.
- ↑ "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Molecular Cell 7 (6): 1233–43. June 2001. doi:10.1016/S1097-2765(01)00257-X. PMID 11430826.
- ↑ "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell 89 (3): 341–7. May 1997. doi:10.1016/S0092-8674(00)80214-7. PMID 9150133.
- ↑ 39.0 39.1 39.2 "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex". Molecular Cell 1 (7): 1021–31. June 1998. doi:10.1016/S1097-2765(00)80102-1. PMID 9651585.
- ↑ "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Molecular Cell 2 (1): 33–42. July 1998. doi:10.1016/S1097-2765(00)80111-2. PMID 9702189.
- ↑ 41.0 41.1 41.2 "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes & Development 15 (5): 603–18. March 2001. doi:10.1101/gad.872801. PMID 11238380.
- ↑ "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology 22 (8): 2743–50. April 2002. doi:10.1128/MCB.22.8.2743-2750.2002. PMID 11909966.
- ↑ "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Molecular and Cellular Biology 20 (6): 2248–59. March 2000. doi:10.1128/MCB.20.6.2248-2259.2000. PMID 10688671.
- ↑ "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. May 1998. doi:10.1038/sj.onc.1202043. PMID 9627120.
- ↑ "The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor". Blood 98 (12): 3290–300. December 2001. doi:10.1182/blood.V98.12.3290. PMID 11719366.
- ↑ "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry 273 (42): 27695–702. October 1998. doi:10.1074/jbc.273.42.27695. PMID 9765306.
Further reading
- "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology 85 (2–5): 401–14. June 2003. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729. https://zenodo.org/record/1260176.
- "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell 80 (5): 767–76. March 1995. doi:10.1016/0092-8674(95)90355-0. PMID 7889570.
- "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal 14 (22): 5646–59. November 1995. doi:10.1002/j.1460-2075.1995.tb00252.x. PMID 8521822.
- "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell 89 (3): 341–7. May 1997. doi:10.1016/S0092-8674(00)80214-7. PMID 9150133.
- "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell 89 (3): 349–56. May 1997. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134.
- "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell 89 (3): 357–64. May 1997. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
- "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal 16 (10): 2892–906. May 1997. doi:10.1093/emboj/16.10.2892. PMID 9184233.
- "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature 391 (6669): 811–4. February 1998. doi:10.1038/35895. PMID 9486654. Bibcode: 1998Natur.391..811L.
- "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. May 1998. doi:10.1038/sj.onc.1202043. PMID 9627120.
- "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry 273 (42): 27695–702. October 1998. doi:10.1074/jbc.273.42.27695. PMID 9765306.
- "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell 95 (2): 279–89. October 1998. doi:10.1016/S0092-8674(00)81758-4. PMID 9790534.
- "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature 395 (6705): 917–21. October 1998. doi:10.1038/27699. PMID 9804427. Bibcode: 1998Natur.395..917T.
- "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. June 1999. doi:10.1093/emboj/18.11.3090. PMID 10357820.
- "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Human Molecular Genetics 8 (9): 1647–55. September 1999. doi:10.1093/hmg/8.9.1647. PMID 10441327.
- "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development 13 (15): 1924–35. August 1999. doi:10.1101/gad.13.15.1924. PMID 10444591.
- "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes & Development 14 (1): 55–66. January 2000. doi:10.1101/gad.14.1.55. PMID 10640276.
- "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Molecular and Cellular Biology 20 (6): 2248–59. March 2000. doi:10.1128/MCB.20.6.2248-2259.2000. PMID 10688671.
- "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". The Journal of Biological Chemistry 275 (26): 19594–602. June 2000. doi:10.1074/jbc.M000254200. PMID 10766745.
External links
- SIN3A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook Sin3Ak-20
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/SIN3A.
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