Biology:MEF2D
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.[1][2]
Interactions
MEF2D has been shown to interact with:
- CABIN1,[3][4]
- EP300,[5][3]
- MAPK7,[6]
- Myocyte-specific enhancer factor 2A,[7]
- NFATC2[8]
- Sp1 transcription factor,[9] and
- YWHAQ.[10]
See also
References
- ↑ "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development 118 (4): 1095–1106. Aug 1993. doi:10.1242/dev.118.4.1095. PMID 8269842.
- ↑ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4209.
- ↑ 3.0 3.1 "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity 13 (1): 85–94. Jul 2000. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.
- ↑ "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science 286 (5440): 790–793. Oct 1999. doi:10.1126/science.286.5440.790. PMID 10531067.
- ↑ "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry 275 (29): 22563–22567. Jul 2000. doi:10.1074/jbc.C000304200. PMID 10825153.
- ↑ "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research 26 (20): 4771–4777. Oct 1998. doi:10.1093/nar/26.20.4771. PMID 9753748.
- ↑ "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry 271 (40): 24927–24933. Oct 1996. doi:10.1074/jbc.271.40.24927. PMID 8798771.
- ↑ "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal 19 (16): 4323–4331. Aug 2000. doi:10.1093/emboj/19.16.4323. PMID 10944115.
- ↑ "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology 39 (1–2): 25–30. Sep 2002. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.
- ↑ "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research 29 (13): 2836–2842. Jul 2001. doi:10.1093/nar/29.13.2836. PMID 11433030.
Further reading
- "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics 29 (3): 704–711. Oct 1995. doi:10.1006/geno.1995.9007. PMID 8575763.
- "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry 271 (40): 24927–24933. Oct 1996. doi:10.1074/jbc.271.40.24927. PMID 8798771.
- "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research 26 (20): 4771–4777. Oct 1998. doi:10.1093/nar/26.20.4771. PMID 9753748.
- "Regulation of the MEF2 family of transcription factors by p38". Molecular and Cellular Biology 19 (1): 21–30. Jan 1999. doi:10.1128/mcb.19.1.21. PMID 9858528.
- "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology 19 (11): 7816–7827. Nov 1999. doi:10.1128/mcb.19.11.7816. PMID 10523670.
- "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proceedings of the National Academy of Sciences of the United States of America 97 (8): 4070–4075. Apr 2000. doi:10.1073/pnas.080064097. PMID 10737771. Bibcode: 2000PNAS...97.4070L.
- "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family". The Journal of Biological Chemistry 275 (24): 18534–18540. Jun 2000. doi:10.1074/jbc.M001573200. PMID 10849446.
- "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal 19 (16): 4323–4331. Aug 2000. doi:10.1093/emboj/19.16.4323. PMID 10944115.
- "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D". The Journal of Biological Chemistry 276 (10): 7575–7585. Mar 2001. doi:10.1074/jbc.M004625200. PMID 11096067.
- "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research 29 (13): 2836–2842. Jul 2001. doi:10.1093/nar/29.13.2836. PMID 11433030.
- "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis". Proceedings of the National Academy of Sciences of the United States of America 99 (6): 3974–3979. Mar 2002. doi:10.1073/pnas.022036399. PMID 11904443. Bibcode: 2002PNAS...99.3974O.
- "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology 39 (1–2): 25–30. Sep 2002. doi:10.1016/S0161-5890(02)00055-X. PMID 12213324.
- "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival". The Journal of Biological Chemistry 278 (42): 41472–41481. Oct 2003. doi:10.1074/jbc.M307245200. PMID 12896970.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–12135. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors". Molecular and Cellular Biology 25 (6): 2273–2287. Mar 2005. doi:10.1128/MCB.25.6.2273-2287.2005. PMID 15743823.
- "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia 19 (5): 806–813. May 2005. doi:10.1038/sj.leu.2403684. PMID 15744350.
External links
- MEF2D+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery | |
|---|---|
|
 |  |
