Biology:USP8
From HandWiki
 Generic protein structure example |
Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[1][2][3]
Interactions
USP8 has been shown to interact with RNF41[4] and STAM2.[5][6]
References
- ↑ "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics 4 (7): 544–58. July 2003. doi:10.1038/nrg1111. PMID 12838346.
- ↑ "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene 16 (13): 1767–72. April 1998. doi:10.1038/sj.onc.1201695. PMID 9582025.
- ↑ "Entrez Gene: USP8 ubiquitin specific peptidase 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9101.
- ↑ "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology 24 (17): 7748–57. September 2004. doi:10.1128/MCB.24.17.7748-7757.2004. PMID 15314180.
- ↑ "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry 278 (48): 48162–8. November 2003. doi:10.1074/jbc.M306677200. PMID 13129930.
- ↑ "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry 275 (48): 37481–7. December 2000. doi:10.1074/jbc.M007251200. PMID 10982817.
Further reading
- "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology 33 (5): 337–52. 1999. doi:10.1080/10409239891204251. PMID 9827704.
- "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 1 (5): 223–9. 1995. doi:10.1093/dnares/1.5.223. PMID 7584044.
- "UBPY: a growth-regulated human ubiquitin isopeptidase". The EMBO Journal 17 (12): 3241–50. June 1998. doi:10.1093/emboj/17.12.3241. PMID 9628861.
- "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry 275 (48): 37481–7. December 2000. doi:10.1074/jbc.M007251200. PMID 10982817.
- "Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1". The Journal of Biological Chemistry 276 (42): 39448–54. October 2001. doi:10.1074/jbc.M103454200. PMID 11500497.
- "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry 278 (48): 48162–8. November 2003. doi:10.1074/jbc.M306677200. PMID 13129930.
- "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nature Immunology 5 (1): 45–54. January 2004. doi:10.1038/ni1017. PMID 14661020.
- "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology 24 (17): 7748–57. September 2004. doi:10.1128/MCB.24.17.7748-7757.2004. PMID 15314180.
- "The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells". Biology of Reproduction 72 (1): 14–21. January 2005. doi:10.1095/biolreprod.104.030866. PMID 15342353.
- "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation". The Journal of Biological Chemistry 281 (18): 12618–24. May 2006. doi:10.1074/jbc.M512615200. PMID 16520378.
- "A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes". Traffic 7 (8): 1017–31. August 2006. doi:10.1111/j.1600-0854.2006.00452.x. PMID 16771824.
- "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". The Journal of Biological Chemistry 281 (49): 38061–70. December 2006. doi:10.1074/jbc.M606704200. PMID 17035239.
PDB gallery | |
|---|---|
|
 |
