Biology:RNF41

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Interactions

RNF41 has been shown to interact with USP8.

See also

• RING finger domain

Further reading

• "Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1". Mol. Cell. Biol. 27 (6): 2180–8. 2007. doi:10.1128/MCB.01245-06. PMID 17210635. 
• "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". J. Biol. Chem. 281 (49): 38061–70. 2006. doi:10.1074/jbc.M606704200. PMID 17035239. 
• "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. 2004. doi:10.1128/MCB.24.17.7748-7757.2004. PMID 15314180. 
• "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. 2004. doi:10.1038/sj.emboj.7600075. PMID 14765125. 
• "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. 2004. doi:10.1074/jbc.M312171200. PMID 14676191. 
• "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. 2002. doi:10.1073/pnas.232580999. PMID 12411582. Bibcode: 2002PNAS...9914843Q. 
• "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. 2002. doi:10.1073/pnas.052709799. PMID 11867753. Bibcode: 2002PNAS...99.2866D. 
• "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors". Blood Cells Mol. Dis. 27 (1): 320–33. 2001. doi:10.1006/bcmd.2001.0390. PMID 11358394. 
• "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 

External links

• RNF41+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• RNF41 human gene location in the UCSC Genome Browser.
• RNF41 human gene details in the UCSC Genome Browser.