Biology:Cas2
From HandWiki
Short description: Protein used in CRISPR
| CRISPR-associated protein 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Streptococcus pyogenes Cas2. PDB: 4QR2 | |||||||||
| Identifiers | |||||||||
| Symbol | cas2 | ||||||||
| Pfam | PF09827 | ||||||||
| InterPro | IPR019199 | ||||||||
| |||||||||
Cas2 is a protein associated with CRISPR that is involved with spacer acquisition. Representative cas2 proteins have been characterized as endonucleases that cleave single-stranded RNAs preferentially within U-rich regions, [1] or as metal-dependent endonucleases targeting double-stranded (ds)DNA [2]
References
- ↑ "A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats". The Journal of Biological Chemistry 283 (29): 20361–71. July 2008. doi:10.1074/jbc.M803225200. PMID 18482976.
- ↑ "Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein". The Journal of Biological Chemistry 287 (43): 35943–52. October 2012. doi:10.1074/jbc.M112.382598. PMID 22942283.
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