Biology:MGAT3
From HandWiki
 Generic protein structure example |
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.[1][2]
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]
References
- ↑ "cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III)". J Biochem 113 (6): 692–8. Oct 1993. doi:10.1093/oxfordjournals.jbchem.a124105. PMID 8370666.
- ↑ 2.0 2.1 "Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4248.
Further reading
- "Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III.". Gene 170 (2): 281–3. 1996. doi:10.1016/0378-1119(95)00818-7. PMID 8666260.
- "Human N-acetylglucosaminyltransferase III gene is transcribed from multiple promoters.". Eur. J. Biochem. 238 (3): 853–61. 1996. doi:10.1111/j.1432-1033.1996.0853w.x. PMID 8706690.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III.". J. Biochem. 128 (4): 609–19. 2000. doi:10.1093/oxfordjournals.jbchem.a022793. PMID 11011143.
- "Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2.". Cancer Invest. 19 (8): 799–807. 2002. doi:10.1081/CNV-100107741. PMID 11768033.
- "Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells.". J. Biol. Chem. 278 (5): 3197–203. 2003. doi:10.1074/jbc.M207870200. PMID 12427758.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus.". J. Biol. Chem. 278 (28): 25295–301. 2003. doi:10.1074/jbc.M301913200. PMID 12716887.
- "Yeast two-hybrid screens implicate DISC1 in brain development and function.". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. 2004. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
- "Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.". J. Biol. Chem. 279 (19): 19747–54. 2004. doi:10.1074/jbc.M311627200. PMID 14998999.
- "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.". Proc. Natl. Acad. Sci. U.S.A. 104 (31): 12849–54. 2007. doi:10.1073/pnas.0701267104. PMID 17652175. Bibcode: 2007PNAS..10412849F.
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