Chemistry:Mannose

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Mannose
Mannose structure.svg
D-Mannopyranose
DL-Mannose.svg
Fischer projections
D-Mannose-chain-3D-balls.png
Names
IUPAC name
Mannose
Systematic IUPAC name
(3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
Identifiers
ChEMBL
ChemSpider
KEGG
MeSH Mannose
UNII
Properties
C6H12O6
Molar mass 180.156 g·mol−1
-102.90·10−6 cm3/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Tracking categories (test):

Mannose is a sugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation of certain proteins. Several congenital disorders of glycosylation are associated with mutations in enzymes involved in mannose metabolism.[1]

Mannose is not an essential nutrient; it can be produced in the human body from glucose, or converted into glucose. Mannose provides 2–5 kcal/g. It is partially excreted in the urine.

Etymology

The root of both "mannose" and "mannitol" is manna, which the Bible describes as the food supplied to the Israelites during their journey in the region of Sinai. Several trees and shrubs can produce a substance called manna, such as the "manna tree" (Fraxinus ornus) from whose secretions mannitol was originally isolated.[citation needed]

Structure

Mannose commonly exists as two different-sized rings, the pyranose (six-membered) form and the furanose (five-membered) form. Each ring closure can have either an alpha or beta configuration at the anomeric position. The chemical rapidly undergoes isomerization among these four forms.[citation needed]

D-Mannose isomers (Haworth projections)
Percent composition[2]
Alpha-D-Mannofuranose.svg
α-D-Mannofuranose
0.6% 		Beta-D-Mannofuranose.svg
β-D-Mannofuranose
0.2%
Alpha-D-Mannopyranose.svg
α-D-Mannopyranose
63.7% 		Beta-D-Mannopyranose.svg
β-D-Mannopyranose
35.5%

Metabolism

Mannose metabolism in human beings

While much of the mannose used in glycosylation is believed to be derived from glucose, in cultured hepatoma cells (cancerous cells from the liver), most of the mannose for glycoprotein biosynthesis comes from extracellular mannose, not glucose.[3] Many of the glycoproteins produced in the liver are secreted into the bloodstream, so dietary mannose is distributed throughout the body.[4]

Mannose is present in numerous glycoconjugates including N-linked glycosylation of proteins. C-Mannosylation is also abundant and can be found in collagen-like regions.[citation needed]

The digestion of many polysaccharides and glycoproteins yields mannose, which is phosphorylated by hexokinase to generate mannose-6-phosphate. Mannose-6-phosphate is converted to fructose-6-phosphate, by the enzyme phosphomannose isomerase, and then enters the glycolytic pathway or is converted to glucose-6-phosphate by the gluconeogenic pathway of hepatocytes.[citation needed]

Mannose is a dominant monosaccharide in N-linked glycosylation, which is a post-translational modification of proteins. It is initiated by the en bloc transfer on Glc3Man9GlcNAc2 to nascent glycoproteins in the endoplasmic reticulum in a co-translational manner as the protein entered through the transport system. Glucose is hydrolyzed on fully folded protein and the mannose moieties are hydrolyzed by ER and Golgi-resident mannosidases. Typically, mature human glycoproteins only contain three mannose residues buried under sequential modification by GlcNAc, galactose, and sialic acid. This is important, as the innate immune system in mammals is geared to recognise exposed mannose residues. This activity is due to the prevalence of mannose residues, in the form of mannans, on the surfaces of yeasts. The human immunodeficiency virus displays considerable amount of mannose residues due to the tight clustering of glycans in its viral spike.[5][6] These mannose residues are the target for broadly neutralizing antibodies.[7]

Biotechnology

Recombinant proteins produced in yeast may be subject to mannose addition in patterns different from those used by mammalian cells.[8] This difference in recombinant proteins from those normally produced in mammalian organisms may influence the effectiveness of vaccines.[citation needed]

Formation

Mannose can be formed by the oxidation of mannitol.[citation needed]

It can also be formed from glucose in the Lobry de Bruyn–van Ekenstein transformation.[citation needed]

Uses

Mannose (D-mannose) is used as a dietary supplement to prevent recurrent urinary tract infections (UTIs).[9][10] (As of 2022), one review found that taking mannose was as effective as antibiotics to prevent UTIs,[9] while another review found that clinical trial quality was too low to allow any conclusion about using D‐mannose to prevent or treat UTIs.[10]

Configuration

Mannose differs from glucose by inversion of the C-2 chiral center. Mannose displays a [math]\displaystyle{ ^4C_1 }[/math] pucker in the solution ring form. This simple change leads to the drastically different biochemistry of the two hexoses. This change has the same effect on the other aldohexoses, as well.[citation needed]

Mannose PTS permease

Mannose XYZ permease complex: entry of PEP which donates a high energy phosphate that gets passed through the transporter system and eventually assist in the entry of mannose (in this example otherwise it would any hexose sugar) and results in the formation of mannose-6-phosphate.

File:MannosePTS.ogv The PEP-dependent sugar transporting phosphotransferase system transports and simultaneously phosphorylates its sugar substrates. Mannose XYZ permease is a member of the family, with this distinct method being used by bacteria for sugar uptake particularly exogenous hexoses in the case of mannose XYZ to release the phosphate esters into the cell cytoplasm in preparation for metabolism primarily through the route of glycolysis.[11] The MANXYZ transporter complex is also involved in infection of E. coli by bacteriophage lambda, with subunit ManY and ManZ being sufficient for proper lambda phage infection.[12] MANXYZ possesses four domains in three polypeptide chains; ManX, ManY, and ManZ. The ManX subunit forms a homodimer that is localized to the cytoplasmic side of the membrane. ManX contains two domains IIA and IIB linked by a hinge peptide with each domain containing a phosphorylation site and phosphoryl transfer occurs between both subunits.[13] ManX can be membrane bound or not.[12] The ManY and ManNZ subunits are hydrophobic integral membrane proteins with six and one transmembrane alpha helical spanner(s).<ref name="Huber 1996">{{Cite journal | doi = 10.1111/j.1432-1033.1996.0810u.x | last1 = Huber | first1 = F. | last2 = Erni | first2 = B. | title = Membrane topology of the mannose transporter of Escherichia coli K12 | journal = European Journal of Biochemistry | volume = 239 | issue = 3 | pages = 810–817 | year = 1996 | pmid = 8774730 | doi-access =

See also

References

  1. ↑ Freeze, H. H.; Sharma, V. (2010). "Metabolic manipulation of glycosylation disorders in humans and animal models". Seminars in Cell & Developmental Biology 21 (6): 655–662. doi:10.1016/j.semcdb.2010.03.011. PMID 20363348. 
  2. ↑ Witczak, Zbigniew J.. "Monosaccharides. Properties". Glycoscience. Chemistry and Chemical Biology I–III. Springer. p. 887. doi:10.1007/978-3-642-56874-9. ISBN 978-3-642-56874-9. 
  3. ↑ Alton, G.; Hasilik, M.; Niehues, R.; Panneerselvam, K.; Etchison, J. R.; Fana, F.; Freeze, H. H. (1998). "Direct utilization of mannose for mammalian glycoprotein biosynthesis". Glycobiology 8 (3): 285–295. doi:10.1093/glycob/8.3.285. PMID 9451038. 
  4. ↑ Davis, J. A.; Freeze, H. H. (2001). "Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse". Biochimica et Biophysica Acta (BBA) - General Subjects 1528 (2–3): 116–126. doi:10.1016/S0304-4165(01)00183-0. PMID 11687298. 
  5. ↑ Pritchard, Laura K.; Spencer, Daniel I. R.; Royle, Louise; Bonomelli, Camille; Seabright, Gemma E.; Behrens, Anna-Janina; Kulp, Daniel W.; Menis, Sergey et al. (2015-06-24). "Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies" (in en). Nature Communications 6: 7479. doi:10.1038/ncomms8479. PMID 26105115. Bibcode: 2015NatCo...6.7479P. 
  6. ↑ Pritchard, Laura K.; Vasiljevic, Snezana; Ozorowski, Gabriel; Seabright, Gemma E.; Cupo, Albert; Ringe, Rajesh; Kim, Helen J.; Sanders, Rogier W. et al. (2015-06-16). "Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers" (in en). Cell Reports 11 (10): 1604–1613. doi:10.1016/j.celrep.2015.05.017. ISSN 2211-1247. PMID 26051934. 
  7. ↑ Crispin, Max; Doores, Katie J (2015-04-01). "Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design". Current Opinion in Virology. Viral pathogenesis • Preventive and therapeutic vaccines 11: 63–69. doi:10.1016/j.coviro.2015.02.002. PMID 25747313. 
  8. ↑ Vlahopoulos, S.; Gritzapis, A. D.; Perez, S. A.; Cacoullos, N.; Papamichail, M.; Baxevanis, C. N. (2009). "Mannose addition by yeast Pichia pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin". Vaccine 27 (34): 4704–4708. doi:10.1016/j.vaccine.2009.05.063. PMID 19520203. 
  9. ↑ 9.0 9.1 Lenger, Stacy M.; Bradley, Megan S.; Thomas, Debbie A.; Bertolet, Marnie H.; Lowder, Jerry L.; Sutcliffe, Siobhan (1 August 2020). "D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis". American Journal of Obstetrics and Gynecology 223 (2): 265.e1–265.e13. doi:10.1016/j.ajog.2020.05.048. PMID 32497610. 
  10. ↑ 10.0 10.1 Cooper, Tess E; Teng, Claris; Howell, Martin; Teixeira-Pinto, Armando; Jaure, Allison; Wong, Germaine (30 August 2022). "D-mannose for preventing and treating urinary tract infections". Cochrane Database of Systematic Reviews 2022 (8). doi:10.1002/14651858.CD013608.pub2. PMID 36041061. 
  11. ↑ Postma, P. W.; Lengeler, J. W.; Jacobson, G. R. (1993). "Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria". Microbiological Reviews 57 (3): 543–594. doi:10.1128/MMBR.57.3.543-594.1993. PMID 8246840. 
  12. ↑ 12.0 12.1 Erni, B.; Zanolari, B. (1985). "The mannose-permease of the bacterial phosphotransferase system. Gene cloning and purification of the enzyme IIMan/IIIMan complex of Escherichia coli". The Journal of Biological Chemistry 260 (29): 15495–15503. doi:10.1016/S0021-9258(17)36282-8. PMID 2999119. 
  13. ↑ Erni, B.; Zanolari, B.; Graff, P.; Kocher, H. P. (1989). "Mannose permease of Escherichia coli. Domain structure and function of the phosphorylating subunit". The Journal of Biological Chemistry 264 (31): 18733–18741. doi:10.1016/S0021-9258(18)51529-5. PMID 2681202. 



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