Biology:SPRED2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1).

Further reading

• "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "Spred is a Sprouty-related suppressor of Ras signalling.". Nature 412 (6847): 647–51. 2001. doi:10.1038/35088082. PMID 11493923. Bibcode: 2001Natur.412..647W. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.". Biochem. Biophys. Res. Commun. 302 (4): 767–72. 2003. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation.". J. Exp. Med. 199 (5): 737–42. 2004. doi:10.1084/jem.20030830. PMID 14981116. 
• "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.". Oncogene 23 (33): 5567–76. 2004. doi:10.1038/sj.onc.1207759. PMID 15184877. 
• "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain.". J. Biomol. NMR 29 (3): 435–6. 2005. doi:10.1023/B:JNMR.0000032526.17586.8c. PMID 15213456. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Expression and subcellular localization of Spred proteins in mouse and human tissues.". Histochem. Cell Biol. 122 (6): 527–38. 2005. doi:10.1007/s00418-004-0725-6. PMID 15580519. 
• "Distinct requirements for the Sprouty domain for functional activity of Spred proteins.". Biochem. J. 388 (Pt 2): 445–54. 2005. doi:10.1042/BJ20041284. PMID 15683364. 
• "Gene disruption of Spred-2 causes dwarfism.". J. Biol. Chem. 280 (31): 28572–80. 2005. doi:10.1074/jbc.M503640200. PMID 15946934. 
• "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.". Oncogene 25 (45): 6056–66. 2006. doi:10.1038/sj.onc.1209635. PMID 16652141. 
• "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. 2007. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949. 

External links

• GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1