Biology:Multisynthetase complex auxiliary component p38

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.[1][2][3]

Function

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.[3]

Interactions

Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin (ligase),[4] P53[2] and KARS.[5][6]

References

  1. ↑ "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene". Genomics 29 (2): 329–34. September 1995. doi:10.1006/geno.1995.9997. PMID 8666379. 
  2. ↑ 2.0 2.1 "AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53". Proceedings of the National Academy of Sciences of the United States of America 105 (32): 11206–11. August 2008. doi:10.1073/pnas.0800297105. PMID 18695251. Bibcode: 2008PNAS..10511206H. 
  3. ↑ 3.0 3.1 "Entrez Gene: JTV1 JTV1 gene". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7965. 
  4. ↑ "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Human Molecular Genetics 12 (12): 1427–37. June 2003. doi:10.1093/hmg/ddg159. PMID 12783850. 
  5. ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
  6. ↑ "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". Journal of Molecular Biology 285 (1): 183–95. January 1999. doi:10.1006/jmbi.1998.2316. PMID 9878398. 

Further reading

  • "Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers". Trends in Biochemical Sciences 30 (10): 569–74. October 2005. doi:10.1016/j.tibs.2005.08.004. PMID 16125937. 
  • "Protective action of series of new mono-pyridinium salts and their effect on "aging" of acetylcholine esterase inhibited by fluostigmine". Polish Journal of Pharmacology and Pharmacy 29 (6): 603–7. 1978. PMID 600859. 
  • "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". The Journal of Biological Chemistry 266 (23): 15398–405. August 1991. doi:10.1016/S0021-9258(18)98629-1. PMID 1651330. 
  • "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". Journal of Molecular Biology 285 (1): 183–95. January 1999. doi:10.1006/jmbi.1998.2316. PMID 9878398. 
  • "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases". The Journal of Biological Chemistry 275 (41): 31682–8. October 2000. doi:10.1074/jbc.M909965199. PMID 10913161. 
  • "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Letters 542 (1–3): 119–24. May 2003. doi:10.1016/S0014-5793(03)00362-4. PMID 12729910. 
  • "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Human Molecular Genetics 12 (12): 1427–37. June 2003. doi:10.1093/hmg/ddg159. PMID 12783850. 
  • "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nature Genetics 34 (3): 330–6. July 2003. doi:10.1038/ng1182. PMID 12819782. 
  • "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation". Cell 119 (2): 195–208. October 2004. doi:10.1016/j.cell.2004.09.030. PMID 15479637. 
  • "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 



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