Biology:SMURF1
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene.[1][2]
Function
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.[2]
Interactions
SMURF1 has been shown to interact with:
References
- ↑ "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation". Nature 400 (6745): 687–93. Sep 1999. doi:10.1038/23293. PMID 10458166. Bibcode: 1999Natur.400..687Z.
- ↑ 2.0 2.1 "Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57154.
- ↑ "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. Apr 2008. doi:10.1515/BC.2008.036. PMID 18208356.
- ↑ "Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1". Nat. Cell Biol. 10 (8): 994–1002. Aug 2008. doi:10.1038/ncb1760. PMID 18641638.
- ↑ "Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells". J. Biol. Chem. 283 (51): 35660–7. Dec 2008. doi:10.1074/jbc.M710496200. PMID 18927080.
Further reading
- "The Smad pathway". Cytokine Growth Factor Rev. 11 (1–2): 5–13. 2000. doi:10.1016/S1359-6101(99)00024-6. PMID 10708948.
- "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. 2001. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation". J. Biol. Chem. 276 (16): 12477–80. 2001. doi:10.1074/jbc.C100008200. PMID 11278251.
- "Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane". J. Biol. Chem. 277 (42): 39919–25. 2002. doi:10.1074/jbc.M201901200. PMID 12151385.
- "Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7". J. Biol. Chem. 278 (12): 10716–21. 2003. doi:10.1074/jbc.M212663200. PMID 12519765.
- "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". EMBO J. 22 (24): 6458–70. 2004. doi:10.1093/emboj/cdg632. PMID 14657019.
- "Regulation of cell polarity and protrusion formation by targeting RhoA for degradation". Science 302 (5651): 1775–9. 2003. doi:10.1126/science.1090772. PMID 14657501. Bibcode: 2003Sci...302.1775W. https://semanticscholar.org/paper/319a6d6163d34e8375c9d3c416e2d2bc0b03521c.
- "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts". J. Clin. Invest. 113 (2): 253–64. 2004. doi:10.1172/JCI16269. PMID 14722617.
- "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation". J. Biol. Chem. 279 (28): 29409–17. 2004. doi:10.1074/jbc.M313120200. PMID 15138260.
- "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking". J. Cell Sci. 117 (Pt 16): 3679–89. 2005. doi:10.1242/jcs.01212. PMID 15252135.
- "Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth". FEBS Lett. 579 (5): 1015–9. 2005. doi:10.1016/j.febslet.2004.12.074. PMID 15710384.
- "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9HCE7 (E3 ubiquitin-protein ligase SMURF1) at the PDBe-KB.
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