Chemistry:Ligustilide
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| Other names
3-Butylidene-4,5-dihydrophthalide
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C12H14O2 | |
| Molar mass | 190.242 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Ligustilide is a natural chemical compound of the dihydrophthalide class. Ligustilide is found in the highest concentration in wild celeries (Apium graveolens).[1][2] It has also been found in Angelica sinensis and a variety of other plants including Todaroa montana.[2]
Potential pharmacology
Because of the traditional use of Angelica sinesis in herbal medicine, particularly traditional Chinese medicine where it is known as dong quai, there has been interest in identifying chemical compounds responsible for its putative pharmacological effects. Ligustilide is typically identified as the principal bioactive component.[3] A variety of in vitro effects of ligustilide have been reported, including antiinflammatory and neuroprotective effects.[4] However, because of the chemical instability of ligustilide, the relevance of these studies to any effects in humans is uncertain.[5]
References
- ↑ "Ligustilide". Human Metabolome Database. https://hmdb.ca/metabolites/HMDB0034277.
- ↑ 2.0 2.1 Gijbels, M.J.M., Fischer, F.C., Scheffer, J.J.C. (1983). "Phthalides in roots of Anethum graveolens and Todaroa montana". Scientia Pharmaceutica 51 (4): 414–417.
- ↑ Yang, F.; Lin, Z. W.; Huang, T. Y.; Chen, T. T.; Cui, J.; Li, M. Y.; Hua, Y. Q. (2019). "Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway". Scientific Reports 9 (1): 6991. doi:10.1038/s41598-019-43518-7. PMID 31061445. Bibcode: 2019NatSR...9.6991Y.
- ↑ Xie, Qingxuan; Zhang, Linlin; Xie, Long; Zheng, Yu; Liu, Kai; Tang, Hailong; Liao, Yanmei; Li, Xiaofang (2020). "Z‐ligustilide: A review of its pharmacokinetics and pharmacology". Phytotherapy Research 34 (8): 1966–1991. doi:10.1002/ptr.6662. PMID 32135035.
- ↑ Duric, Kemal; Liu, Yang; Chen, Shao-Nong; Lankin, David C.; Nikolic, Dejan; McAlpine, James B.; Friesen, J. Brent; Pauli, Guido F. (2019). "Studying Mass Balance and the Stability of (Z)-Ligustilide from Angelica sinensis Helps to Bridge a Botanical Instability–Bioactivity Chasm". Journal of Natural Products 82 (9): 2400–2408. doi:10.1021/acs.jnatprod.8b00962. PMID 31478376.
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