Chemistry:Phthalide
Phthalide is an organic chemical compound with the molecular formula C8H6O2. It is a white solid and the simplest benzo lactone. It is prepared from hydroxymethylbenzoic acid.[1]
Phthalides
The phthalide core is found in a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).
Examples
-
Phenolphthalein -
Tetrachlorophthalide -
5-bromophthalide [64169-34-2] is used in the synthesis of Roxadustat and Citalopram.
3-(4'-chlorophenyl)phthalide is a chemical that serves function in the synthesis of Setazindol[2] & Chlortalidone.[3]
Synthesis
Phthalide synthesis:[4]
Uses
Phthalide has known uses in the synthesis of hydralazine,[3][5] & pipethiadene.[6][7]
Phthalide is used in the synthesis of dibenzosuberone.
References
- ↑ J. H. Gardner; C. A. Naylor, Jr (1936). "Phthalide". Organic Syntheses 16: 71. doi:10.15227/orgsyn.016.0071.
- ↑ Dictionary of drugs: chemical data, structures, and bibliographies (1st ed.). Chapman and Hall. 1990. ISBN 9780412273001.
- ↑ 3.0 3.1 Synthesis of essential drugs (1st ed.). Elsevier. 2006. ISBN 9780444521668.
- ↑ "PHTHALIDE". Organic Syntheses 16: 71. 1936. doi:10.15227/orgsyn.016.0071. http://orgsyn.org/demo.aspx?prep=CV2P0526.
- ↑ "Hydrazinderivate der Phtalazin‐ und Pyridazinreihe". Helvetica Chimica Acta 34 (1): 195–210. January 1951. doi:10.1002/hlca.19510340122. https://onlinelibrary.wiley.com/doi/10.1002/hlca.19510340122.
- ↑ "Pipethiadene Tartrate". Drugs of the Future 8 (4): 334. 1983. doi:10.1358/dof.1983.008.04.65210. ISSN 0377-8282. http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=65210&p_IsPs=N.
- ↑ "Antiaminic agents derived from thieno[2,3-c-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds"]. Collection of Czechoslovak Chemical Communications 48 (2): 623–641. 1983. doi:10.1135/cccc19830623. http://cccc.uochb.cas.cz/48/2/0623/.
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