Medicine:XXXYY syndrome

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Short description: Chromosomal disorder
XXXYY syndrome
Other names49,XXXYY
XXXYY syndrome karyotype.jpg
Karyotype of XXXYY syndrome
SymptomsIntellectual disability, facial dysmorphisms, genital anomalies
Usual onsetConception
DurationLifelong
CausesNondisjunction
Diagnostic methodKaryotype
FrequencyLess than 1 in 1000000

XXXYY syndrome, also known as 49,XXXYY, is a chromosomal disorder in which a male has three copies of the X chromosome and two copies of the Y chromosome. XXXYY syndrome is exceptionally rare, with only eight recorded cases. Little is known about its presentation, but associated characteristics include intellectual disability, anomalies of the external genitalia, and characteristic physical and facial features. It is not caused by characteristics of the parents, but rather occurs via nondisjunction, a random event in gamete development. The karyotype observed in the syndrome is formally known as 49,XXXYY, which represents the 49 chromosomes observed in the disorder as compared to the 46 in normal human development.

XXXYY syndrome was first recorded in 1963. Its long-term prognosis is poorly understood; while the condition as reported in the medical literature is relatively severe, it is unknown if there are milder cases that have not come to diagnostic attention.

Presentation

Due to its exceptional rarity, little is known about XXXYY syndrome. There are no unbiased[note 1] descriptions of the disorder; all living XXXYY males reported in the medical literature were diagnosed after birth due to symptoms, and it is unknown if there are milder cases that have not come to diagnostic attention.[1][2][3] All known cases of the syndrome have been associated with developmental delay or intellectual disability.[1][2] Adult XXXYY men have generally been reported as having moderate to severe intellectual disability;[1] moderate intellectual disability is defined by an adult cognitive capacity similar to that of a six- to eight-year-old and the ability to acquire basic living and employment skills with support, while the severe form is associated with an adult capability similar to that of a three- to five-year-old, with long-term dependence on caregivers.[4]

Sex chromosome aneuploidies[note 2] are generally associated with tall stature, particularly polysomies of the Y chromosome, but data on tetrasomy and pentasomy disorders[note 3] is less clear and some seem associated with short stature;[6][7] adult XXXYY men in the medical literature have ranged in height from 170 centimetres (5 ft 7 in) to 192 centimetres (6 ft 4 in).[1] The disorder seems associated with dysmorphic features (unusual facial features), with reported examples including hypertelorism (wide-spaced eyes), a prominent forehead and wide nasal bridge, epicanthic folds, and micrognathia (small chin).[1][2][3] Other unusual features reported include clinodactyly (incurved pinky fingers) and radioulnar synostosis (fusion of the long bones in the forearm). These findings are common to sex chromosome aneuploidies.[2][8] XXXYY syndrome is thought to be associated with similar congenital issues to other sex chromosome tetrasomy and pentasomy disorders, such as heart and kidney malformations, dental issues, and minor facial dysmorphology.[1]

As very few cases of XXXYY syndrome in adult men have been reported, drawing conclusions about physical development and hormonal functioning is difficult. Only one XXXYY man recorded in the medical literature has undergone hormone testing. He was found to have low testosterone, alongside elevated lutenizing hormone and follicle stimulating hormone.[1] According to literature reviews, genital abnormalities are a hallmark of the syndrome. Reported findings include micropenis and cryptorchidism (undescended testes).[1][2][3] Adults generally have sparse or absent facial hair. Some men have been described as having high-pitched voices.[2]

Little is understood about the psychological and behavioural phenotype of XXXYY syndrome. One review described behaviour as "generally passive", a common description of people with X-chromosome polysomy.[3] The literature is divided on whether autism or autistic features are common, though they have been reported in other X- and Y-chromosome disorders. Behavioural "outbursts" are mentioned by two reviews.[1][2][3] X- and Y-chromosome polysomies are both associated with behavioural and psychological sequelae. Because XXXYY syndrome involves both X and Y polysomy, it is unclear what effects are caused by each.[3]

Causes

XXXYY syndrome is caused by two extra copies of the X chromosome alongside one extra copy of the Y chromosome, producing a total complement of 49 chromosomes rather than the usual 46.[1] Sex chromosome aneuploidies are the most frequent form of aneuploidy in humans.[9] Though a 48-chromosome complement involving the autosomes would be unsurvivable, 49,XXXYY and other high-level sex chromosome aneuploidies, such as tetrasomy X, pentasomy X, XYYY syndrome, XYYYY syndrome, and XXXXY syndrome, are survivable with relatively mild phenotypes due to the paucity of genes vital to basic development on the sex chromosomes.[3]

Sex chromosome aneuploidies are caused by nondisjunction, a process through which gametes (eggs or sperm) with too many or too few chromosomes are produced. In nondisjunction, homologous chromosomes or sister chromatids fail to separate properly when producing gametes.[10] XXXYY syndrome, by its nature, requires multiple steps of nondisjunction. Possible causes include fertilization of a normal egg by an XXYY sperm, fertilization of an XX egg by an XYY sperm, or fertilization of an XXX egg by a YY sperm.[2] Nondisjunction is generally a random event not related to any characteristic of the parents, and almost never recurs in their future children.[11]

Diagnosis

Chromosome aneuploidies such as XXXYY syndrome are diagnosed through the process of karyotyping, or chromosome testing.[12]

One recorded case of the disorder was diagnosed prenatally via amniocentesis, but did not survive to birth due to termination of the prenatally diagnosed fetus by decision of the pregnant woman and her husband after they were informed of the abnormal chromosome complement of the fetus and its clinical implication.[13] This XXXYY case was one of five known instances when a poly X and Y karyotype has been prenatally diagnosed; other four cases involved poly X and Y karyotypes different from XXXYY.[3]

All other reported cases of XXXYY syndrome were diagnosed postnatally.[2][13] Sex chromosome aneuploidies can only be diagnosed via conclusive genetic testing, not on the basis of clinical examination, due to their nonspecific phenotypes. Such disorders are underdiagnosed, and when diagnosis does occur, it is often late.[1][3]

Prognosis

The long-term prognosis of XXXYY syndrome is little-understood. Few adults with the disorder have been reported, and there are no reports of people diagnosed prenatally who survived to birth. This lack of prognosis information is common in sex chromosome tetrasomy and pentasomy; though longitudal studies exist for the sex chromosome trisomies, higher-level aneuploidies are far rarer and information more sparse. Good prognosis appears linked to strong parental and personal support; people with such disorders whose caregivers have acted as advocates for their success have been reported as achieving at higher personal and social levels than the general portrait in the medical literature.[1][2][3]

Epidemiology

XXXYY syndrome is exceptionally rare. Only eight cases of the condition have been reported in the medical literature, and the prevalence is estimated to be below 1 in 1000000.[1][2] Sex chromosome tetrasomy and pentasomy disorders are thought to be underdiagnosed, and people may exist who have milder versions of such conditions than are generally reported.[3] XXXYY syndrome only occurs in males, as the Y chromosome is in most cases necessary for male sexual development; this is not changed by the presence of multiple X chromosomes.[14][15]

History

XXXYY syndrome was first recorded in 1963, in a 26-year-old man with a moderate intellectual disability living at the Utah State Training School who was ascertained due to having physical traits of Klinefelter syndrome. By that time, three men with XXYY syndrome had been reported.[16] 49,XXXYY was one of the later sex chromosome aneuploidies to be discovered, being preceded by Turner,[17] Klinefelter,[18] and trisomy X[19] in 1959, XXYY syndrome in 1960,[20] and XYY[21] and tetrasomy X[22] in 1961. The 49,XXXYY karyotype was not reported again until 1974, highlighting the rarity of the syndrome.[23] By the time of Linden, Bender, and Robinson's seminal review of sex chromosome tetrasomy and pentasomy in 1995, five cases of XXXYY syndrome had been reported.[3] (As of 2023), three cases of XXXYY syndrome have been diagnosed in the 21st century.[2]

Early research on sex chromosome aneuploidies suffered from ascertainment bias. Patients were screened in prisons and institutions, forming an image of such conditions as severely disabling. This was particularly marked for Y-chromosome polysomy; early research into men with extra Y chromosomes focused on criminality, depicting such men as inclined to violent and unlawful behaviour. These assumptions were later disproven by longitudinal studies of people diagnosed at birth with sex chromosome trisomies, which found people with 47,XXY, 47,XXX, and 47,XYY karyotypes blended into the general population and had little unusual propensity for criminality. Despite these advances regarding sex chromosome trisomies, the tetrasomy and pentasomy variants remain understudied. Due to their extreme rarity, none were detected in these cohort studies, and no unbiased information exists on their long-term prognosis.[3][24]

Notes

  1. ↑ the biases are imposed by limitations of the study population, see History section for details
  2. ↑ aneuploidy is the presence of too many or too few chromosomes in a cell[5]
  3. ↑ in the context of sex chromosome disorders specifically, tetrasomy refers to karyotypes with four sex chromosomes, and pentasomy to ones with five[3]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Verhoeven, Willem MA; Egger, Jos IM; Mergler, Sandra; Meijer, Tom AA; Pfundt, Rolph; Willemsen, Marjorlein H (2022). "A Patient with Moderate Intellectual Disability and 49, XXXYY Karyotype". International Journal of Genetic Medicine 15 (1): 2799–2806. doi:10.2147/IJGM.S348844. PMID 35300132. 
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Alekri, Ali; Busehail, Maryam; Rhayel, Noorhan; Almosawi, Sayed Mohamed (2023). "XXXYY variant of Klinefelter syndrome: A case report". International Journal of Health Sciences 17 (3): 39–45. PMID 37151746. 
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Linden, Mary G; Bender, Bruce G; Robinson, Arthur (October 1995). "Sex chromosome tetrasomy and pentasomy". Pediatrics 96 (4): 672–682. doi:10.1542/peds.96.4.672. PMID 7567329. https://pediatrics.aappublications.org/content/96/4/672.short. 
  4. ↑ "A clinical primer on intellectual disability". Translational Pediatrics 9 (1): S23–S35. February 2020. doi:10.21037/tp.2020.02.02. PMID 32206581. 
  5. ↑ "Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants". Environmental Health 15 (97): 97. 12 October 2016. doi:10.1186/s12940-016-0180-6. PMID 27729050. Bibcode: 2016EnvHe..15...97M. 
  6. ↑ Aksglaede, Lise; Skakkebæk, Niels Erik; Juul, Anders (2 February 2012). "Sex Chromosome Aneuploidy and Anthropometry". in Preedy, Victor R. Handbook of Anthropometry (1 ed.). Springer. pp. 1619–1634. ISBN 978-1-4419-1788-1. 
  7. ↑ Ottesen, Anne Marie; Aksglaede, Lise; Garn, Inger; Tartaglia, Nicole; Tassone, Flora; Gravholt, Claus H; Bojesen, Anders; Sørensen, Kaspar et al. (May 2010). "Increased number of sex chromosomes affects height in a nonlinear fashion: A study of 305 patients with sex chromosome aneuploidy". American Journal of Medical Genetics Part A 152A (5): 1206–1212. doi:10.1002/ajmg.a.33334. PMID 20425825. 
  8. ↑ Visootsak, Jeannie; Graham, John M (24 October 2006). "Klinefelter syndrome and other sex chromosomal aneuploidies". Orphanet Journal of Rare Diseases 1 (42): 42. doi:10.1186/1750-1172-1-42. PMID 17062147. 
  9. ↑ Templado, Cristina; Uroz, L; Estop, A (October 2013). "New insights on the origin and relevance of aneuploidy in human spermatozoa". Molecular Human Reproduction 19 (10): 634–643. doi:10.1093/molehr/gat039. PMID 23720770. 
  10. ↑ Mikwar, Myy; MacFarlane, Amanda J; Marchetti, Francesco (4 July 2020). "Mechanisms of oocyte aneuploidy associated with advanced maternal age". Mutation Research/Reviews in Mutation Research 785 (1): 108320. doi:10.1016/j.mrrev.2020.108320. PMID 32800274. 
  11. ↑ "Trisomy X Syndrome (47,XXX)". Reference Module in Biomedical Sciences. 2018. doi:10.1016/B978-0-12-801238-3.65368-0. ISBN 9780128012383. 
  12. ↑ O'Connor, Clare (2008). "Chromosomal Abnormalities: Aneuploidies". Nature Education. https://www.nature.com/scitable/topicpage/chromosomal-abnormalities-aneuploidies-290/. 
  13. ↑ 13.0 13.1 Benn, Peter A; Sugarman, Mitchell; Greco, M Alba; Harris, Gloria; DeGuire, George B; Hsu, Lillian YF (October 1982). "Prenatal diagnosis of 49, XXXYY". Prenatal Diagnosis 2 (4): 309–312. doi:10.1002/pd.1970020411. PMID 7156028. 
  14. ↑ "49,XXXYY syndrome". Genetic and Rare Diseases Information Center. February 2023. https://rarediseases.info.nih.gov/diseases/10922/49-xxxyy-syndrome. 
  15. ↑ Rey, Rodolfo; Josso, Nathalie; Racine, Chrystèle (27 May 2020). "Sexual Differentiation". Endotext. South Dartmouth, Massachussetts: MDText. https://www.ncbi.nlm.nih.gov/books/NBK279001/. Retrieved 14 October 2023. 
  16. ↑ Bray, Patrick; Josephine, Ann (1963). "An XXXYY Sex-Chromosome Anomaly". JAMA 184 (3): 179–182. doi:10.1001/jama.1963.03700160055007. PMID 14015109. 
  17. ↑ "A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome)". Lancet 273 (7075): 711–713. 1959. doi:10.1016/S0140-6736(59)91893-8. PMID 13642858. 
  18. ↑ "A case of human intersexuality having a possible XXY sex-determining mechanism". Nature 183 (4657): 302–303. 31 January 1959. doi:10.1038/183302a0. PMID 13632697. Bibcode: 1959Natur.183..302J. 
  19. ↑ "Evidence for the existence of the human 'super female'". Lancet 274 (7100): 423–425. 26 September 1959. doi:10.1016/S0140-6736(59)90415-5. PMID 14406377. 
  20. ↑ "The 'double male': a new chromosome constitution in Klinefelter's syndrome". Lancet 276 (7147): 492–493. 27 August 1960. doi:10.1016/S0140-6736(60)91624-X. 
  21. ↑ "An XYY human male". Lancet 278 (7200): 488–489. 26 August 1961. doi:10.1016/S0140-6736(61)92459-X. PMID 13746118. 
  22. ↑ "An XXXX sex chromosome complex in two mentally defective females". Canadian Medical Association Journal 84 (3): 131–137. 21 January 1961. PMID 13690988. 
  23. ↑ Lecluse-van der Bilt, FA; Hagemeijer, A; Smit, EME; Visser, HKA; Vaandrager, GJ (1974). "An infant with an XXXYY karyotype". Clinical Genetics 5 (3): 263–270. doi:10.1111/j.1399-0004.1974.tb01693.x. PMID 4838894. 
  24. ↑ Re, Laura; Birkhoff, Jutta M (2015). "The 47,XYY syndrome, 50 years of certainties and doubts: A systematic review". Aggression and Violent Behavior 22 (1): 9–17. doi:10.1016/j.avb.2015.02.003. 



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