Medicine:Ligneous conjunctivitis
| Ligneous conjunctivitis | |
|---|---|
| Other names | Conjunctivitis lignosa[1] |
| Specialty | Ophthalmology |
Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva).[2] It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia.[3] It can be sight-threatening,[3] and death can occasionally occur from pulmonary involvement.[citation needed]
It has been speculated hola ligneous conjunctivitis may be a manifestation of IgG4-related disease (IgG4-RD) involving the conjunctiva.[4]
Pathogenesis
Histopathological findings from affected humans indicate that wound healing is impaired due to a deficiency in plasmin-mediated extracellular fibrinolysis.[2] Episodes may be triggered by minor trauma, eye surgery, or by systemic events such as infections or antifibrinolytic therapy.[3] Histology shows amorphous subepithelial deposits of eosinophilic material consisting predominantly of fibrin.[clarification needed]
Diagnosis
Treatment
Ligneous conjunctivitis may be managed by topical treatments of plasminogen,[2] topical and subconjunctival fresh frozen plasma,[2] and fibrinolytic therapy.[5]
References
- ↑ RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Ligneous conjunctivitis" (in en). https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=97231.
- ↑ 2.0 2.1 2.2 2.3 Schuster, V.; Seregard, S. (2003). "Ligneous conjunctivitis". Survey of Ophthalmology 48 (4): 369–388. doi:10.1016/s0039-6257(03)00056-0. PMID 12850227.
- ↑ 3.0 3.1 3.2 "Ligneous conjunctivitis". Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231.
- ↑ Chiang Wei-Yu; iu Ting-Ting; Huang Wan-Ting; Kuo Ming-Tse (9 September 2016). "Co-existing ligneous conjunctivitis and IgG4-related disease". Indian Journal of Ophthalmology 64 (7): 532–534. doi:10.4103/0301-4738.190154. PMID 27609168. PMC 5026081. http://www.ijo.in/article.asp?issn=0301-4738;year=2016;volume=64;issue=7;spage=532;epage=534;aulast=Chiang.
- ↑ "Ligneous Conjunctivitis". Ocular Pathology. http://www.images.missionforvisionusa.org/anatomy/2006/03/what-is-ligneous-conjunctivitis.html.
External links
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