Chemistry:Compound 2f (SARM)
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Short description: Chemical compound
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| Formula | C14H13F3N2O2 |
| Molar mass | 298.265 g·mol−1 |
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Compound 2f (SARM) is a drug which acts as a selective androgen receptor modulator (SARM), originally developed by Takeda Pharmaceutical for the treatment of prostate cancer. It is a potent but tissue specific androgen agonist with an EC50 of 4.7nM, producing anabolic effects on muscles and in the central nervous system but with little effect on the prostate gland, and inducing sexual behaviour in animal studies.[1][2][3]
See also
References
- ↑ Hasuoka A, "Pyrrolidin-2-one derivatives as androgen receptor modulator", US patent 8420694, issued 16 April 2013, assigned to Takeda Pharmaceutical Co Ltd.
- ↑ "Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate". Bioorganic & Medicinal Chemistry 25 (13): 3330–3349. July 2017. doi:10.1016/j.bmc.2017.04.018. PMID 28454849.
- ↑ "An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer". International Journal of Molecular Sciences 22 (4): 2124. February 2021. doi:10.3390/ijms22042124. PMID 33672769.
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