Chemistry:SSR-180,575
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Short description: Chemical compound
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| Formula | C21H19ClN4O2 |
| Molar mass | 394.86 g·mol−1 |
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SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.[1][2][3][4]
See also
References
- ↑ "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics 301 (3): 1067–78. June 2002. doi:10.1124/jpet.301.3.1067. PMID 12023539.
- ↑ "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics 306 (3): 828–37. September 2003. doi:10.1124/jpet.103.052068. PMID 12928523.
- ↑ "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology 15 (8): 2152–60. August 2004. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.
- ↑ "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics 110 (3): 503–24. June 2006. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.
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