Chemistry:Amonafide
From HandWiki
Short description: Chemical compound
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| Trade names | Xanafide, Quinamed |
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| Formula | C16H17N3O3 |
| Molar mass | 299.330 g·mol−1 |
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Amonafide (originally AS1413) (INN, trade names Quinamed and Xanafide) was a drug that was being studied in the treatment of cancer. It belongs to a novel family of chemotherapeutic drugs called Naphthalimides and is a potential topoisomerase inhibitor and DNA intercalator.[1][2]
It was being developed as an anti-cancer therapy by Antisoma.[3]
(As of 2008), it is in Phase III clinical trials. e.g. In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).[4] In June 2010, it gained an FDA Fast Track Status for the treatment of Secondary Acute Myeloid Leukaemia.[citation needed]
See also
References
- ↑ "Amonafide: a potential role in treating acute myeloid leukemia". Expert Opinion on Investigational Drugs 20 (7): 995–1003. July 2011. doi:10.1517/13543784.2011.585756. PMID 21591994.
- ↑ "Amonafide: a future in treatment of resistant and secondary acute myeloid leukemia?". Expert Review of Hematology 5 (1): 17–26. February 2012. doi:10.1586/ehm.11.68. PMID 22272701.
- ↑ "Antisoma's Shares Plummet 70% as Cancer Candidate Bombs in Phase III NSCLC Trial". Genetic Engineering & Biotechnology News. 29 March 2010. http://www.genengnews.com/news/bnitem.aspx?name=78979622.
- ↑ Clinical trial number NCT00715637 for "Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study" at ClinicalTrials.gov
External links
- Amonafide entry in the public domain NCI Dictionary of Cancer Terms
- Clinical trials of amonafide at ClinicalTrials.gov
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
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