Chemistry:Olorofim
From HandWiki
Short description: Chemical compound
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| Other names | F901318 |
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| Formula | C28H27FN6O2 |
| Molar mass | 498.562 g·mol−1 |
Olorofim (F901318) is an experimental antifungal drug being developed for invasive mold infections.[1][2] If approved it would be a first-in-class medication (for the orotomide class). In 2023, the FDA decided not to approve the drug and to request more data about the safety of the drug.[3] Olorofim does not inhibit growth of Candida species.[2]
References
- ↑ Neoh, Chin Fen; Jeong, Wirawan; Kong, David CM; Slavin, Monica A (2023). "The antifungal pipeline for invasive fungal diseases: what does the future hold?". Expert Review of Anti-infective Therapy 21 (6): 577–594. doi:10.1080/14787210.2023.2203383. PMID 37057677.
- ↑ 2.0 2.1 Wiederhold, Nathan P. (2020). "Review of the Novel Investigational Antifungal Olorofim". Journal of Fungi 6 (3): 122. doi:10.3390/jof6030122. ISSN 2309-608X. PMID 32751765.
- ↑ "FDA Passes on Olorofim Despite Critical Need for Antifungals" (in en). https://www.medscape.com/viewarticle/993520.
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