Chemistry:Solasonine
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| C45H73NO16 | |
| Molar mass | 884.07 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Solasonine is a glycoalkaloid that is found in Solanum plants of the family Solanaceae.[1] Solasonine is a poisonous chemical compound when used at high levels. It is a glycoside of solasodine. Glycoalkaloids such as Solasonine have various applications including pharmacology, cancer treatments and even a role as a pesticide.
High levels of glycoalkaloids are toxic to humans due to their ability to disrupt cell-membrane function.[2] There is a loss of membrane integrity which puts the cell at risk for apoptosis (cell death) due to the ability of any chemical coming into contact with the cell.
Solasonine was one component of the unsuccessful experimental cancer drug candidate Coramsine.
Side Effects
Although, solasonine has anti-infection properties it has many adverse side effects as a steroidal glycoalkaloid.[3] These side effects include low blood pressure, a decrease in respiratory activity, rapid heart beat etc.[3] These side effects are the direct result of the cytotoxic properties of solasonine (at high levels) that lead to disrupted cell membranes.
See also
References
- ↑ Everist, S.L. (1981). Poisonous Plants of Australia. Angus & Robertson. ISBN 0-207-14228-9.
- ↑ Al Sinani, S.S.S.; Eltayeb, E.A. (September 2017). "The steroidal glycoalkaloids solamargine and solasonine in Solanum plants". South African Journal of Botany 112: 253–269. doi:10.1016/j.sajb.2017.06.002. ISSN 0254-6299.
- ↑ 3.0 3.1 Yang, Jun; Huang, Wenjing; Tan, Wenfu (2016). "Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity". Molecules 21 (10): 1364. doi:10.3390/molecules21101364. PMID 27754442.
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