Chemistry:CVN45502
From HandWiki
Short description: Chemical compound
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| Formula | C19H19F3N8O |
| Molar mass | 432.411 g·mol−1 |
CVN45502 is a selective hypocretin (orexin) receptor 1 antagonist. It significantly reduces food intake and body weight in a mouse model of obesity.[1] Although HCRTR1 variants are significantly correlated with body weight in humans, it is not known if the drug has psychiatric side effects or could be combined with GLP-1 agonists.[2]
References
- ↑ Schneeberger, Marc; Brice, Nicola L.; Pellegrino, Kyle; Parolari, Luca; Shaked, Jordan T.; Page, Keith J.; Marchildon, François; Barrows, Douglas W. et al. (November 2022). "Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction". Nature Metabolism 4 (11): 1495–1513. doi:10.1038/s42255-022-00677-8. ISSN 2522-5812. PMC 9684079. https://pubmed.ncbi.nlm.nih.gov/36411386/.
- ↑ Tsang, Anthony; Blouet, Clemence (April 2023). "A pipeline for identification and validation of brain targets for weight loss" (in en). Nature Reviews Endocrinology 19 (4): 190–191. doi:10.1038/s41574-023-00803-w. ISSN 1759-5037. https://www.nature.com/articles/s41574-023-00803-w.
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