Chemistry:CD38-IN-78c
From HandWiki
Short description: Chemical compound
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| Formula | C22H27N3O3S |
| Molar mass | 413.54 g·mol−1 |
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CD38-IN-78c is a drug which acts as a potent and selective inhibitor of the glycoprotein enzyme CD38.[1] In animal studies it boosts levels of nicotinamide adenine dinucleotide (NAD+) in tissues via inhibition of CD38 mediated breakdown of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), and has been shown to ameliorate metabolic dysfunction associated with the aging process.[2] It also has potential therapeutic application in the treatment of asthma.[3]
References
- ↑ "Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors". Journal of Medicinal Chemistry 58 (8): 3548–71. April 2015. doi:10.1021/jm502009h. PMID 25828863.
- ↑ "A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline". Cell Metabolism 27 (5): 1081–1095.e10. May 2018. doi:10.1016/j.cmet.2018.03.016. PMID 29719225.
- ↑ "CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets". Pharmacology & Therapeutics 172: 116–126. 2017. doi:10.1016/j.pharmthera.2016.12.002. PMID 27939939.
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