Chemistry:NV-5440

Short description: Chemical compound

NV-5440

Identifiers
IUPAC name 2-[4-[5-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-2,4-dimethylbenzoyl]piperazin-1-yl]benzenesulfonamide
CAS Number	2226614-88-4
PubChem CID	134500648
ChemSpider	98644474
Chemical and physical data
Formula	C31H36N6O3S
Molar mass	572.73 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(C=C1CN2CCN(CC2)C3=CC=CC=C3C#N)C(=O)N4CCN(CC4)C5=CC=CC=C5S(=O)(=O)N)C
InChI InChI=1S/C31H36N6O3S/c1-23-19-24(2)27(20-26(23)22-34-11-13-35(14-12-34)28-8-4-3-7-25(28)21-32)31(38)37-17-15-36(16-18-37)29-9-5-6-10-30(29)41(33,39)40/h3-10,19-20H,11-18,22H2,1-2H3,(H2,33,39,40) Key:BREWSTIKWAQLCH-UHFFFAOYSA-N

NV-5440 is a drug which acts as both a non-specific inhibitor of the glucose transporters and also a selective inhibitor of mTORC1, with no significant action at the related mTORC2 subtype. Compounds of this type have potential application in the treatment of cancer, and it is also used for research into the links between calorie restriction and longevity.