Chemistry:NV-5440
From HandWiki
Short description: Chemical compound
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| Formula | C31H36N6O3S |
| Molar mass | 572.73 g·mol−1 |
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NV-5440 is a drug which acts as both a non-specific inhibitor of the glucose transporters and also a selective inhibitor of mTORC1, with no significant action at the related mTORC2 subtype. Compounds of this type have potential application in the treatment of cancer, and it is also used for research into the links between calorie restriction and longevity.[1][2][3]
References
- ↑ "Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters". Cell Chemical Biology 26 (9): 1203–1213.e13. September 2019. doi:10.1016/j.chembiol.2019.05.009. PMID 31231029.
- ↑ "Development of Glucose Transporter (GLUT) Inhibitors". European Journal of Organic Chemistry 2020 (16): 2321–2329. May 2020. doi:10.1002/ejoc.201901353. PMID 32421048.
- ↑ "Small-Molecule Inhibition of Glucose Transporters GLUT-1-4". ChemBioChem 21 (1–2): 45–52. January 2020. doi:10.1002/cbic.201900544. PMID 31553512.
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